产品名称

英文名称：Chymostatin

同义词

Chymostatin、51759-76-3、2-[[1-(2-amino-1,4,5,6-tetrahydropyrimidin-6-yl)-2-[[4-methyl-1-oxo-1-[(1-oxo-3-phenylpropan-2-yl)amino]pentan-2-yl]amino]-2-oxoethyl]carbamoylamino]-3-phenylpropanoic acid、9076-44-2、n-{[1-(2-amino-3,4,5,6-tetrahydropyrimidin-4-yl)-、N-(Nα-羰基-Cpd-X-Phe-al)-Phe(Cpd = 环氧环氧环己烷)(环氧环氧环己烷= [S,S]-α-(2-亚氨基六氢-4-嘧啶基)甘氨酸)

产品性质

CAS编号：9076-44-2

分子式：C31H41N7O6

分子量：607.7

MDL号：MFCD00071059

PubChem编号：103535

别名：N-(Nα-羰基-Cpd-X-Phe-al)-Phe(Cpd = 环氧环氧环己烷)(环氧环氧环己烷= [S,S]-α-(2-亚氨基六氢-4-嘧啶基)甘氨酸)

英文别名：Chymostatin|51759-76-3|2-[[1-(2-amino-1,4,5,6-tetrahydropyrimidin-6-yl)-2-[[4-methyl-1-oxo-1-[(1-oxo-3-phenylpropan-2-yl)amino]pentan-2-yl]amino]-2-oxoethyl]carbamoylamino]-3-phenylpropanoic acid|9076-44-2|n-{[1-(2-amino-3,4,5,6-tetrahydropyrimidin-4-yl)-

规格或纯度：≥95%

英文名称：Chymostatin

生化机理：抑制溶酶体组织蛋白酶 B 和可溶性钙激活蛋白酶。许多幼嫩的植物组织都表达一种胰凝乳蛋白酶抑制剂敏感性丝氨酸蛋白酶。 糜蛋白酶抑制蛋白是许多蛋白酶的强抑制剂，包括糜蛋白酶、木瓜蛋白酶、糜蛋白酶样丝氨酸蛋白酶、糜蛋白酶和溶酶体半胱氨酸蛋白酶如组织蛋白酶 A、B、C、B、H 和 L。它对人白细胞弹性蛋白酶的抑制作用较弱。在终浓度为 100～200 μg/ml (10～100 μM) 时有效。胰凝乳蛋白酶抑制剂通常包含在与植物提取物一起使用的蛋白酶抑制剂混合物中。高效的胰凝乳蛋白酶抑制剂（IC 50 = 250 nM）。抑制组织蛋白酶A，B和C。抑制木瓜蛋白酶。

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Chymostatin is a bioactive peptide protease inhibitor that contains chymostatin A as a major form. The compound specifically inhibits chymotrypsin (CTR) (ID50 = 150 ηg/ml), papain (ID50 = 7.5 μg/ml), and cathepsin G along with most cysteine proteases such as cathepsin A, B, H, and L. The compound has been noted as a strong inhibitor of cathepsins A, B, and C. Chymostatin at an effective concentration of 10 to 100 μM weakly inhibits human leukocyte Elastase-1. In rat muscle homogenates chymostatin inhibited the protease cathepsin B and other soluble Ca2+ activated proteases. In the same study, chymostatin decreased protein break down by 20-40% without inhibiting protein production.Chymostatin has been used in a study that determined that molecular calculations are useful for evaluating the interactions between ligands, including inhibitors and homologous enzymes, in docking models. Chymostatin has also been used in a study to investigate the norovirus protease as an attractive target for antiviral drμg development.Chymostatin is a bioactive peptide protease inhibitor that contains chymostatin A as a major form. The compound specifically inhibits chymotrypsin (CTR) (ID50 = 150 ηg/ml), papain (ID50 = 7.5 μg/ml), and cathepsin G along with most cysteine proteases such as cathepsin A, B, H, and L. The compound has been noted as a strong inhibitor of cathepsins A, B, and C. Chymostatin at an effective concentration of 10 to 100 μM weakly inhibits human leukocyte Elastase-1. In rat muscle homogenates chymostatin inhibited the protease cathepsin B and other soluble Ca2+ activated proteases. In the same study, chymostatin decreased protein break down by 20-40% without inhibiting protein production.

IUPAC Name：2-[[1-(2-amino-1,4,5,6-tetrahydropyrimidin-6-yl)-2-[[4-methyl-1-oxo-1-[(1-oxo-3-phenylpropan-2-yl)amino]pentan-2-yl]amino]-2-oxoethyl]carbamoylamino]-3-phenylpropanoic acid

INCHI：InChI=1S/C31H41N7O6/c1-19(2)15-24(27(40)34-22(18-39)16-20-9-5-3-6-10-20)35-28(41)26(23-13-14-33-30(32)36-23)38-31(44)37-25(29(42)43)17-21-11-7-4-8-12-21/h3-12,18-19,22-26H,13-17H2,1-2H3,(H,34,40)(H,35,41)(H,42,43)(H3,32,33,36)(H2,37,38,44)

InChi Key：MRXDGVXSWIXTQL-UHFFFAOYSA-N

Canonical SMILES：CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C=O)NC(=O)C(C2CCN=C(N2)N)NC(=O)NC(CC3=CC=CC=C3)C(=O)O

Isomeric SMILES：CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C=O)NC(=O)C(C2CCN=C(N2)N)NC(=O)NC(CC3=CC=CC=C3)C(=O)O

WGK Germany：3

RTECS：GC3047700

PubChem CID：103535

溶解性：Soluble in DMSO or 5% acetic acid

密度：1.34

敏感性：对湿度敏感

个人防护装备：Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

产品包装