产品名称

英文名称：CHAPS

同义词

CHAPS、75621-03-3、3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE、3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate、CHEBI1418、QBP25342AG、3-[dimethyl-[3-[[(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,、3-[(3-胆酰胺丙基)二甲基-氨]-1-丙烷磺酸盐、3-((3-胆汁氨丙基)二甲基胺)-1-丙磺酸、3-[(3-胆酰胺丙基)二甲氨基]丙磺酸内盐

产品性质

CAS编号：75621-03-3

分子式：C32H58N2O7S

分子量：614.88

MDL号：MFCD00012116

PubChem编号：107670

别名：3-[(3-胆酰胺丙基)二甲基-氨]-1-丙烷磺酸盐|3-((3-胆汁氨丙基)二甲基胺)-1-丙磺酸|3-[(3-胆酰胺丙基)二甲氨基]丙磺酸内盐

英文别名：CHAPS|75621-03-3|3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE|3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate|CHEBI1418|QBP25342AG|3-[dimethyl-[3-[[(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,

规格或纯度：98%

英文名称：CHAPS

生化机理：CHAPS是两性离子非变性去污剂，用于溶解膜蛋白。

储存温度：2-8°C储存,充氩

运输条件：冰袋运输

产品介绍：CHAPS 是一种用于膜生物化学的非变性两性离子洗涤剂。可用于溶解膜蛋白以及打断蛋白-蛋白相互作用。CHAPS 具有低胶束分子量 (6,150) 和高临界胶束浓度 (6-10mM)，因此可通过透析从样品中除去。它也适合在等电聚焦和二维电泳中用于溶解蛋白质。CHAPS 常用于非变性（无尿素）等电聚焦，已发现它对某些亚细胞制备物和植物蛋白能够得出优异的分辨率。通常将介于 2-4% (w/v) 间的浓度用于等电聚焦凝胶。CHAPS is a non-denaturing, zwitterionic detergent derived from cholic acid. CHAPS is often used as a detergent in the solubilization and purification of membrane proteins for several advantageous reasons. CHAPS detergent is non-denaturing to membrane proteins, can solubilize proteins, disaggregate protein-protein interactions and is electrically neutral. CHAPS is also useful in ion exchange chromatography and isoelectric focusing as it is zwitterionic and does not exhibit a net charge between pH 2 to 12. The critical micelle concentration of CHAPS is 6-10mM.A non-denaturing, zwitterionic detergent for membrane proteinsApplicationBuffer; zwitterionic nondenaturing detergent for solubilizing membrane proteins CHAPS is used in the laboratory to dissolve biological macromolecules such as proteins. It acts as a non-denaturing solvent used in purification of membrane proteins. It is also useful in conjunction with nonionic detergents like Triton X-100. Further, it is used as a non-denaturing zwitterionic detergent for membrane biochemistry.

IUPAC Name：3-[dimethyl-[3-[[(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]propyl]azaniumyl]propane-1-sulfonate

INCHI：InChI=1S/C32H58N2O7S/c1-21(8-11-29(38)33-14-6-15-34(4,5)16-7-17-42(39,40)41)24-9-10-25-30-26(20-28(37)32(24,25)3)31(2)13-12-23(35)18-22(31)19-27(30)36/h21-28,30,35-37H,6-20H2,1-5H3,(H-,33,38,39,40,41)/t21-,22+,23-,24-,25+,26+,27-,28+,30+,31+,32-/m1/s1

InChi Key：UMCMPZBLKLEWAF-BCTGSCMUSA-N

Canonical SMILES：CC(CCC(=O)NCCC[N+](C)(C)CCCS(=O)(=O)[O-])C1CCC2C1(C(CC3C2C(CC4C3(CCC(C4)O)C)O)O)C

Isomeric SMILES：C[C@H](CCC(=O)NCCC[N+](C)(C)CCCS(=O)(=O)[O-])[C@H]1CC[C@@H]2[C@@]1([C@H](C[C@H]3[C@H]2[C@@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)O)C

WGK Germany：3

PubChem CID：107670

溶解性：Slightly soluble in water

密度：1.01

敏感性：对湿度敏感

熔点：156-158℃

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

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