产品名称

英文名称：Lamotrigine

同义词

lamotrigine、84057-84-1、6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine、Lamictal、Lamictal Cd、Lamictal XR、Lamotrigina、Lamotriginum、Lamitor、BW 430C、Lamotriginum [Latin]、Lamictal ODT、Lamotrigina [Spanish]、BW-430C、Labileno、3,5-Diamino-6-(2,3-dichlorophenyl)-、拉莫三嗪、LTG、3,5-二氨基-6-(2,3-二氯苯基)-1,2,4-三嗪、6-(2,3-二氯苯基)-1,2,4-三嗪-3,5-二胺、胃肠道 267119X

产品性质

CAS编号：84057-84-1

分子式：C9H7Cl2N5

分子量：256.09

EC号：281-901-8

MDL号：MFCD00865333

PubChem编号：3878

别名：拉莫三嗪|LTG|3,5-二氨基-6-(2,3-二氯苯基)-1,2,4-三嗪|6-(2,3-二氯苯基)-1,2,4-三嗪-3,5-二胺|胃肠道 267119X

英文别名：lamotrigine|84057-84-1|6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine|Lamictal|Lamictal Cd|Lamictal XR|Lamotrigina|Lamotriginum|Lamitor|BW 430C|Lamotriginum [Latin]|Lamictal ODT|Lamotrigina [Spanish]|BW-430C|Labileno|3,5-Diamino-6-(2,3-dichlorophenyl)-

规格或纯度：≥98%

英文名称：Lamotrigine

生化机理：Lamotrigine is a phenyltriazine sodium channel protein inhibitor of presynaptic neurons. Studies indicate that Lamotrigine blocked sustained repetitive firing of neurons in a dose dependent manner in cultured mouse spinal cords. These studies indicate that Lamotrigine is effective at suppressing the release of glutamate and aspartate, but have no effect on acetylcholine and GABA release. Lamotrigine is inactivated by liver microsomes, via hepatic glucuronidation. It is believed that Lamotrigine modulates the fast voltage-dependent sodium currents in a manner similar to phenytoin and carbamazepine. Futhermore, Lamotrigine displays a small frequency dependent inhibition of depolarized potentials that result from sodium currents. Lamotrigine is an inhibitor of Serotonin.Anticonvulsant. Active in vivo and orally bioavailable. Various pharmacological activities including sodium channel blocking (K i = 9 μM). Selectively inhibits seizure discharges over normal neuronal activity.

储存温度：2-8°C储存,充氩

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Lamotrigine是一种新型抗惊厥药剂，作用于人类血小板和大鼠脑突触体，抑制5-羟色胺(5-HT)吸收，IC50分别为240 μM和474 μM。A sodium channel protein inhibitor.Lamotrigine is a novel anticonvulsant drug for inhibition of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes, and also is a sodium channel blocker.A sodium channel protein inhibitor.

ALogP：1.4

IUPAC Name：6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine

INCHI：InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16)

InChi Key：PYZRQGJRPPTADH-UHFFFAOYSA-N

Canonical SMILES：C1=CC(=C(C(=C1)Cl)Cl)C2=C(N=C(N=N2)N)N

Isomeric SMILES：C1=CC(=C(C(=C1)Cl)Cl)C2=C(N=C(N=N2)N)N

WGK Germany：3

RTECS：XY5850700

PubChem CID：3878

DrugBank Ligand：DB00555

CAS Registry No.：84057-84-1

ChEBI：CHEBI138727

ChEMBL Ligand：CHEMBL741

BindingDB Ligand：50031299

Wikipedia：Lamotrigine

PEP：lamotrigine

DrugCentral Ligand：1540

溶解性：Soluble in DMSO (12 mg/mL) at 40 °C, ethanol (12 mg/mL) at 40 °C, DMF (25 mg/mL), methanol, and dilute hydrochloric acid (slightly soluble). Insoluble in water.

敏感性：对热和空气敏感

熔点：216-218°C

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowed

预防措施声明：P321,P405,P501,P264,P270,P330,P301+P316

Merck Index：5353

个人防护装备：Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

产品包装