产品名称

英文名称：SL-327

同义词

SL327、305350-87-2、SL-327、MEK1/2 Inhibitor、SL 327、3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile、(Z)-3-amino-3-(4-aminophenylthio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile、alpha-[amino[(4-aminophenyl)thio]methylene]-2-(trifluo、3-氨基-3-[(4-氨基苯基)硫代]-2-[2-(三氟甲基)苯基]丙烯腈、α-[氨基[(4-氨基苯基)硫代]亚甲基]-2-(三氟甲基)苯乙腈

产品性质

CAS编号：305350-87-2

分子式：C16H12F3N3S

分子量：335.35

MDL号：MFCD06411432

PubChem编号：9549284

别名：3-氨基-3-[(4-氨基苯基)硫代]-2-[2-(三氟甲基)苯基]丙烯腈|α-[氨基[(4-氨基苯基)硫代]亚甲基]-2-(三氟甲基)苯乙腈

英文别名：SL327|305350-87-2|SL-327|MEK1/2 Inhibitor|SL 327|3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile|(Z)-3-amino-3-(4-aminophenylthio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile|alpha-[amino[(4-aminophenyl)thio]methylene]-2-(trifluo

规格或纯度：98%(total of isomer)

英文名称：SL-327

生化机理：SL-327 is a cell-permeable vinylogous cyanamide that acts as a selective inhibitor of MEK-1 and MEK-2 (IC50 = 0.18 and 0.22 μM respectively). SL-327 has been shown to block hippocampal LTP via inhibition of the MAPK/ERK cascade, which prevents CREB and Elk-1 phosphorylation, and LTP-dependent gene induction, resulting in rapidly decaying LTP, while being uncompetitive with respect to ATP. Brain penetrant in vivo, blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration. SL-327 has also been shown to inhibit ERK1, MEK-3/p38, MEK-4, JNK, and PKC activities when used at higher concentrations.Centrally active, brain penetrant selective MEK1 and MEK2 inhibitor (IC 50 values in in vitro assays are 0.18 and 0.22 μM, respectively).

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：SL327 抑制 MEK1 和 MEK2，IC50 分别为 180 nM 和 220 nM。SL327 inhibits MEK1 and MEK2, with IC50 values of 180 nM and 220 nM, respectively.

IUPAC Name：(Z)-3-amino-3-(4-aminophenyl)sulfanyl-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile

INCHI：InChI=1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+

InChi Key：JLOXTZFYJNCPIS-FYWRMAATSA-N

Canonical SMILES：C1=CC=C(C(=C1)C(=C(N)SC2=CC=C(C=C2)N)C#N)C(F)(F)F

Isomeric SMILES：C1=CC=C(C(=C1)/C(=C(\N)/SC2=CC=C(C=C2)N)/C#N)C(F)(F)F

WGK Germany：3

PubChem CID：9549284

ChEMBL Ligand：CHEMBL261237

CAS Registry No.：305350-87-2

溶解性：DMSO 4 mg/mL Water <1 mg/mL Ethanol 7 mg/mL

敏感性：对光敏感、对空气敏感、对潮湿敏感、对热敏感

熔点：128 °C

个人防护装备：Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

产品包装