产品名称

英文名称：Amprenavir

同义词

amprenavir、161814-49-9、Agenerase、Prozei、VX-478、141W94、KVX-478、Vertex VX478、VX 478、Amprenavir (agenerase)、DRG-0258、CHEBI40050、HSDB 7157、UNII-5S0W860XNR、5S0W860XNR、(3S)-Tetrahydro-3-furanyl ((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydr、141W94, KVX-478, Prozei, 安普那韦, VX-478, 安瑞那韦

产品性质

CAS编号：161814-49-9

分子式：C25H35N3O6S

分子量：505.63

PubChem编号：65016

别名：141W94, KVX-478, Prozei, 安普那韦, VX-478, 安瑞那韦

英文别名：amprenavir|161814-49-9|Agenerase|Prozei|VX-478|141W94|KVX-478|Vertex VX478|VX 478|Amprenavir (agenerase)|DRG-0258|CHEBI40050|HSDB 7157|UNII-5S0W860XNR|5S0W860XNR|(3S)-Tetrahydro-3-furanyl ((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydr

规格或纯度：≥97%

英文名称：Amprenavir

生化机理：DescriptionIC50 Value 0.6nM (Ki); Against wild-type clinical HIV isolates14.6 +/- 12.5 ng/mL (mean +/- SD) [1].Amprenavir (Agenerase, GlaxoSmithKline) is a HIV protease inhibitor used to treat HIV infection. It was approved by the Food and Drμg Administration on April 15, 1999, for twice-a-day dosing instead of needing to be taken every eight hours.in vitro Amprenavir has an enzyme inhibition constant (Ki = 0.6 nM) that falls within the Ki range of the other protease inhibitors. Amprenavir's in vitro 50% inhibitory concentration (IC50) against wild-type clinical HIV isolates is 14.6 +/- 12.5 ng/mL (mean +/- SD) [1]. Amprenavir had direct inhibitory effects on invasion of Huh-7 hepatocarcinoma cell lines, inhibiting MMP proteolytic activation [2].in vivo Amprenavir was able to promote regression of hepatocarcinoma growth in vivo by anti-angiogenetic and overall anti-tumor activities, independently by PI3K/AKT related pathways that at today is one of the more sμggestive hypothesis to explain the anti-tumor effects of the different protease inhibitors [2]. Amprenavir efficiently activated PXR and induced PXR target gene expression in vitro and in vivo. Short-term exposure to amprenavirsignificantly increased plasma total cholesterol and atherogenic low-density lipoprotein cholesterol levels in wild-type mice, but not in PXR-deficient mice [3]. Amprenavir has been approved for adults and children; the recommended capsule doses are 1200 mg twice daily for adults and 20 mg/kg twice daily or 15 mg/kg 3 times daily for children < 13 years of age or adolescents < 50 kg [1].Clinical trial A Study to Compare Three Doses of T-20 When Given in Combination With Abacavir, Amprenavir, Ritonavir, and Efavirenz to HIV-Infected Adults. Phase 2

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Amprenavir (VX-478, 141W94, KVX-478)是一种人类免疫缺陷病毒(HIV)蛋白酶抑制剂，作用于野生型HIV分离株，IC50为14.6 ng/ml。Amprenavir is a second-generation drug derived from hydroxyethylamine sulfonamide.

ALogP：2.9

IUPAC Name：[(3S)-oxolan-3-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate

INCHI：InChI=1S/C25H35N3O6S/c1-18(2)15-28(35(31,32)22-10-8-20(26)9-11-22)16-24(29)23(14-19-6-4-3-5-7-19)27-25(30)34-21-12-13-33-17-21/h3-11,18,21,23-24,29H,12-17,26H2,1-2H3,(H,27,30)/t21-,23-,24+/m0/s1

InChi Key：YMARZQAQMVYCKC-OEMFJLHTSA-N

Canonical SMILES：CC(C)CN(CC(C(CC1=CC=CC=C1)NC(=O)OC2CCOC2)O)S(=O)(=O)C3=CC=C(C=C3)N

Isomeric SMILES：CC(C)CN(C[C@H]([C@H](CC1=CC=CC=C1)NC(=O)O[C@H]2CCOC2)O)S(=O)(=O)C3=CC=C(C=C3)N

WGK Germany：3

PubChem CID：65016

溶解性：DMSO 16 mg/mL Water <1 mg/mL Ethanol 101 mg/mL

敏感性：易吸湿

象形图：

信号词：Warning

危险声明：H351 Suspected of causing cancerH412 Harmful to aquatic life with long lasting effectsH361 Suspected of damaging fertility or the unborn child

预防措施声明：P273,P280,P405,P501,P203,P318

产品包装