产品名称

英文名称：5-Fluoroisatin

同义词

5-Fluoroisatin、443-69-6、5-Fluoro-1H-indole-2,3-dione、5-fluoroindoline-2,3-dione、5-fluoro isatin、5-FLUORO-2,3-INDOLEDIONE、MFCD00022795、5-fluoro-2,3-dihydro-1H-indole-2,3-dione、1H-INDOLE-2,3-DIONE, 5-FLUORO-、5-fluoro-2,3-indolinedione、5-Fluoroindole-2,3-dio、5-氟吲哚醌、5-氟二氢吲哚-2,3-二酮、5-氟-2,3-吲哚啉二酮

产品性质

CAS编号：443-69-6

分子式：C8H4FNO2

分子量：165.12

Beilstein号：21(3/4)5004

MDL号：MFCD00022795

PubChem编号：236566

别名：5-氟吲哚醌|5-氟二氢吲哚-2,3-二酮|5-氟-2,3-吲哚啉二酮

英文别名：5-Fluoroisatin|443-69-6|5-Fluoro-1H-indole-2,3-dione|5-fluoroindoline-2,3-dione|5-fluoro isatin|5-FLUORO-2,3-INDOLEDIONE|MFCD00022795|5-fluoro-2,3-dihydro-1H-indole-2,3-dione|1H-INDOLE-2,3-DIONE, 5-FLUORO-|5-fluoro-2,3-indolinedione|5-Fluoroindole-2,3-dio

规格或纯度：>98.0%(HPLC)

英文名称：5-Fluoroisatin

运输条件：常规运输

产品介绍：5-Fluoroisatin has been reported as the precursor of the Sunitinib (Sutent) drug. 5-Fluoroisatin has been approved by the Food and Drugs Administration (FDA) in 2006 for the treatment of renal cell carcinoma (RCC) and gastrointestinal stromal tumor (GIST).5-Fluoroisatin may be used as reaction-based probe for live-cell detection of peroxynitrite by 19F magnetic resonance spectroscopy;in non-invasive detection of peroxynitrite (ONOO(-)) formation in living lung epithelial cells stimulated with interferon-γ (IFN-γ);in the synthesis of bis-Schiff bases, via condensation with aromatic primary bis-amines in water suspension medium without using any organic solvent or acid catalyst;in the synthesis of 3-acetonyl-5-fluoro-3-hydroxyoxindole Reactant for preparation ofSpiro[indole-thiazolidinones] as biologically relevan synthesis scaffolds;Potential antimycobacterial agents;Inhibitors of c-Met kinase;Inhibitors of TAK1 kinase;Herpes simplex virus inhibitors;IKKβ inhibitors; Inhibitors of vitiligo disease; Potential drug candidates with anti-HIV activity and anti-tubercular activity

PubChem SID：488188887

IUPAC Name：5-fluoro-1H-indole-2,3-dione

INCHI：InChI=1S/C8H4FNO2/c9-4-1-2-6-5(3-4)7(11)8(12)10-6/h1-3H,(H,10,11,12)

InChi Key：GKODDAXOSGGARJ-UHFFFAOYSA-N

Canonical SMILES：C1=CC2=C(C=C1F)C(=O)C(=O)N2

Isomeric SMILES：C1=CC2=C(C=C1F)C(=O)C(=O)N2

WGK Germany：3

PubChem CID：236566

Reaxy-Rn：131241

熔点：224-230°C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

个人防护装备：dust mask type N95 (US)， Eyeshields， Gloves

产品包装