产品名称

英文名称：Reserpine

同义词

reserpine、50-55-5、Serpalan、Serpasil、Apoplon、Serpivite、Alserin、Hypersil、Sandril、Deserpine、Elserpine、Hiserpia、Rau-Sed、Rausedyl、Rauwasedin、Reserpin、Serpanray、Resine、Rivasin、Serpate、Ascoserpina、Austrapine、Bioserpine、Carditivo、Carrserp、Enipresser、Escaspere、Ese、利血平、蛇根碱、血安平、蛇根草素

产品性质

CAS编号：50-55-5

分子式：C33H40N2O9

分子量：608.68

Beilstein号：102014

EC号：200-047-9

MDL号：MFCD00005091

PubChem编号：5770

别名：利血平|蛇根碱|血安平|蛇根草素

英文别名：reserpine|50-55-5|Serpalan|Serpasil|Apoplon|Serpivite|Alserin|Hypersil|Sandril|Deserpine|Elserpine|Hiserpia|Rau-Sed|Rausedyl|Rauwasedin|Reserpin|Serpanray|Resine|Rivasin|Serpate|Ascoserpina|Austrapine|Bioserpine|Carditivo|Carrserp|Enipresser|Escaspere|Ese

规格或纯度：≥98.0% (HPLC)

英文名称：Reserpine

生化机理：不可逆水泡单胺转运蛋白（VMAT2）拮抗剂。持久的生物胺耗竭。防止生物胺转运到突触小泡和嗜铬颗粒中。耗尽生物胺储备。降压和抗精神病药。

应用：抑制儿茶酚胺(catecholamines)和5-羟色胺（serotonin）的吸收。

储存温度：2-8°C储存,充氩

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Reserpine has displayed a capacity to inhibit the transport of biogenic amines into synaptic vesicles and adrenal chromaffin granules. The mechanism behind this inhibition has been illuminated as an irreversible binding to the vesicular amine transporter. Furthermore, Reserpine has been reported to interfere with dopamine transporter activity and potently inhibit synaptosomal dopamine uptake. Reserpine is an inhibitor of VMAT 2.抑制儿茶酚胺(catecholamines)和5-羟色胺（serotonin）的吸收。Reserpine has displayed a capacity to inhibit the transport of biogenic amines into synaptic vesicles and adrenal chromaffin granules. The mechanism behind this inhibition has been illuminated as an irreversible binding to the vesicular amine transporter. Furthermore, Reserpine has been reported to interfere with dopamine transporter activity and potently inhibit synaptosomal dopamine uptake. Reserpine is an inhibitor of VMAT 2.Inhibits vesicular uptake of catecholamines and serotonin.

ALogP：4

IUPAC Name：methyl (1R,15S,17R,18R,19S,20S)-6,18-dimethoxy-17-(3,4,5-trimethoxybenzoyl)oxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate

INCHI：InChI=1S/C33H40N2O9/c1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19/h7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/t18-,22+,24-,27-,28+,31+/m1/s1

InChi Key：QEVHRUUCFGRFIF-MDEJGZGSSA-N

Canonical SMILES：COC1C(CC2CN3CCC4=C(C3CC2C1C(=O)OC)NC5=C4C=CC(=C5)OC)OC(=O)C6=CC(=C(C(=C6)OC)OC)OC

Isomeric SMILES：CO[C@H]1[C@@H](C[C@@H]2CN3CCC4=C([C@H]3C[C@@H]2[C@@H]1C(=O)OC)NC5=C4C=CC(=C5)OC)OC(=O)C6=CC(=C(C(=C6)OC)OC)OC

WGK Germany：3

PubChem CID：5770

UN Number：3077

Packing Group：III

DrugBank Ligand：DB00206

Wikipedia：Reserpine

CAS Registry No.：50-55-5

ChEMBL Ligand：CHEMBL772

DrugCentral Ligand：2370

溶解性：Soluble in DMSO (100 mM), chloroform (10 mg/ml), water (<1 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).

密度：1.32

敏感性：对空气敏感

比旋光度：177° (C=1,DMF)

闪点(℉)：22 °C

闪点(℃)：22°C

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

Class：9

Merck Index：8145

个人防护装备：Eyeshields,Faceshields,full-face respirator (US),Gloves,multi-purpose combination respirator cartridge (US),type ABEK (EN14387) respirator filter

产品包装