产品名称

英文名称：LatanoprostAcid

同义词

Latanoprost acid、41639-83-2、Phxa 85、Phxa-85、CHEBI63925、Latanprost Free Acid、EJ85341990、PHXA85、(5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoic acid、(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenyl

产品性质

CAS编号：41639-83-2

分子式：C23H34O5

分子量：390.51

EC号：682-021-0

MDL号：MFCD08056084

PubChem编号：6441636

英文别名：Latanoprost acid|41639-83-2|Phxa 85|Phxa-85|CHEBI63925|Latanprost Free Acid|EJ85341990|PHXA85|(5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoic acid|(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenyl

规格或纯度：≥98%

英文名称：LatanoprostAcid

生化机理：Potent, selective FP prostanoid receptor agonist, F-series prostaglandin analog. 200 times as potent as isopropyl ester form.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Latanoprost (free acid) is a metabolite of Latanoprost, an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drμg. Latanoprost is an isopropyl ester, a prodrμg form which is converted to latanoprost (free acid) by endogenous esterase enzymes. The free acid form is 200 times more potent than latanoprost as an FP receptor ligand for the human recombinant FP receptor. Latanoprost is the isopropyl ester of a PGF2α analog containing an aromatic group (17-phenyl) in the ω-chain. Lat-FA is the corresponding carboxylic acid of this analog. Lat-FA is a potent FP receptor agonist with an EC50 of 3.6 nM for human FP receptors, which is twice the potency of PGF2α. Therefore making Latanoprost (free acid) is an activator of PGF2αR.An F-series prostaglandin (PG) analog.Latanoprost (free acid) is a metabolite of Latanoprost, an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. Latanoprost is an isopropyl ester, a prodrug form which is converted to latanoprost (free acid) by endogenous esterase enzymes. The free acid form is 200 times more potent than latanoprost as an FP receptor ligand for the human recombinant FP receptor. Latanoprost is the isopropyl ester of a PGF2α analog containing an aromatic group (17-phenyl) in the ω-chain. Lat-FA is the corresponding carboxylic acid of this analog. Lat-FA is a potent FP receptor agonist with an EC50 of 3.6 nM for human FP receptors, which is twice the potency of PGF2α. Therefore making Latanoprost (free acid) is an activator of PGF2αR.An F-series prostaglandin (PG) analog.

IUPAC Name：(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoic acid

INCHI：InChI=1S/C23H34O5/c24-18(13-12-17-8-4-3-5-9-17)14-15-20-19(21(25)16-22(20)26)10-6-1-2-7-11-23(27)28/h1,3-6,8-9,18-22,24-26H,2,7,10-16H2,(H,27,28)/b6-1-/t18-,19+,20+,21-,22+/m0/s1

InChi Key：HNPFPERDNWXAGS-NFVOFSAMSA-N

Canonical SMILES：C1C(C(C(C1O)CC=CCCCC(=O)O)CCC(CCC2=CC=CC=C2)O)O

Isomeric SMILES：C1[C@H]([C@@H]([C@H]([C@H]1O)C/C=C\CCCC(=O)O)CC[C@H](CCC2=CC=CC=C2)O)O

WGK Germany：3

关联CAS：41639-83-2

PubChem CID：6441636

MeSH Entry Terms：PhXa 85;PhXa-85;PhXa85

溶解性：Soluble in water (>0.8 mg/ml at 25 °C), ethanol (~100 mg/ml), DMSO (~100 mg/ml), DMF (~100 mg/ml), and methanol.

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowedH360 May damage fertility or the unborn childH361 Suspected of damaging fertility or the unborn child

预防措施声明：P280,P321,P405,P501,P264,P270,P330,P203,P301+P316,P318

个人防护装备：Eyeshields， Gloves

产品包装