产品名称

英文名称：BIX-01294

同义词

BIX-01294、935693-62-2、N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine、BIX01294、BIX 01294 trihydrochloride hydrate、CHEMBL569864、2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperi

产品性质

CAS编号：935693-62-2

分子式：C28H38N6O2

分子量：490.64

PubChem编号：25150857

英文别名：BIX-01294|935693-62-2|N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine|BIX01294|BIX 01294 trihydrochloride hydrate|CHEMBL569864|2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperi

规格或纯度：≥98%

英文名称：BIX-01294

生化机理：BIX-01294, a diazepin-quinazolinamine derivative, is a selective inhibitor of G9a histone methyl transferase (G9a HMTase) that impairs G9a HMTase and generation of H3K9me2 in vitro. In its inhibition of the histone lysine methyltransferases, BIX-01294 does not compete with cofactor S-adenosyl-methionine. G9a HMTase regulates gene expression including one of the pluripotency genes Oct4. It is reported that BIX-01294 enhances reprogramming efficiency of neural progenitor cells to the same levels as when four transcription factors (Oct4, Klf4, Sox2 and c-Myc) were introduced to somatic cells for generation of induced pluripotent stem cells. BIX-01294 and valproic acid, a histone deacetylase (HDAC) inhibitor, may replace the requirement for ectopic OCT4 (POU5F1) and cMyc respectively in pluripotent stem cell induction (iPS) recipes.Potent, selective G9a and G9a-like protein histone lysine methyltransferase inhibitor (IC 50 values are 1.7 and 0.7 μM at G9a and G9a-like protein, respectively). No activity at other HMT up to 37 μM. Antimalarial agent. Active in vitro .

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：BIX01294是G9a组蛋白甲基转移酶（HMTase）抑制剂，IC50为2.7 μM。A selective large conductance calcium activated potassium channel activatorBIX01294 is an inhibitor of G9a histone methyltransferase with IC50 of 2.7 μMA selective large conductance calcium activated potassium channel activator

IUPAC Name：N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine

INCHI：InChI=1S/C28H38N6O2/c1-32-12-7-13-34(17-16-32)28-30-24-19-26(36-3)25(35-2)18-23(24)27(31-28)29-22-10-14-33(15-11-22)20-21-8-5-4-6-9-21/h4-6,8-9,18-19,22H,7,10-17,20H2,1-3H3,(H,29,30,31)

InChi Key：OSXFATOLZGZLSK-UHFFFAOYSA-N

Canonical SMILES：CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)CC5=CC=CC=C5)OC)OC

Isomeric SMILES：CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)CC5=CC=CC=C5)OC)OC

PubChem CID：25150857

CAS Registry No.：935693-62-2

ChEMBL Ligand：CHEMBL569864

RCSB PDB Ligand：Q4A

溶解性：≥5.1 mg/mL in EtOH with ultrasonic; ≥51.2 mg/mL in H2O

密度：1.6

折光率：1.54

熔点：178.44°C

产品包装