产品名称

英文名称：Cladribine

同义词

Cladribine、2-Chloro-2'-deoxyadenosine、4291-63-8、Leustatin、2-Chlorodeoxyadenosine、2-CdA、Chlorodeoxyadenosine、Litak、ADENOSINE, 2-CHLORO-2'-DEOXY-、CldAdo、2-Chloro-2'-deoxy-beta-adenosine、mavenclad、Cladaribine、2CdA、RWJ 26251、2-chloro-deoxyadenosine、2ClAdo、RWJ、CdA、克拉利宾、2-氯-2'-脱氧腺嘌呤核苷、2-氯-9-(2-脱氧-β-D-呋喃阿拉伯糖基)腺嘌呤

产品性质

CAS编号：4291-63-8

分子式：C10H12ClN5O3

分子量：285.69

MDL号：MFCD00153939

PubChem编号：20279

别名：CdA|克拉利宾|2-氯-2'-脱氧腺嘌呤核苷|2-氯-9-(2-脱氧-β-D-呋喃阿拉伯糖基)腺嘌呤

英文别名：Cladribine|2-Chloro-2'-deoxyadenosine|4291-63-8|Leustatin|2-Chlorodeoxyadenosine|2-CdA|Chlorodeoxyadenosine|Litak|ADENOSINE, 2-CHLORO-2'-DEOXY-|CldAdo|2-Chloro-2'-deoxy-beta-adenosine|mavenclad|Cladaribine|2CdA|RWJ 26251|2-chloro-deoxyadenosine|2ClAdo|RWJ

规格或纯度：≥98%

英文名称：Cladribine

生化机理：Deoxyadenosine analog resistant to adenosine deaminase; antileukemic with immunosuppressive activity

应用：It is a chlorinated purine nucleoside with activity against lymphoproliferative disorders, such as hairy cell leukemia (HCL) and multiple myeloma (MM). 2-CdA resists ADA degradation and is phosphorylated to CdATP in lymphocytes. CdATP incorporation into DNA induces strand breaks and the activation of apoptosis. 2-CdA may also be used in studies involving the inhibition of DNA polymerase(s). Cladribiane, like fludarabine, is a prodrug that is must be phosphorylated intracellularly to the monophosphate by the nuclear/cytosol enzyme deoxycytidine kinase (dCK) and possibly by the mitochondrial enzyme deoxyguanosine kinase (dGK).

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Cladribine是一种腺苷脱氨酶抑制剂，作用于U266， RPMI8226，和MM1.S细胞，IC50分别约为2.43 μM， 0.75 μM，和0.18 μM。最大吸收波长265(EtOH aq.) nmCladribine is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectivelyIt is a chlorinated purine nucleoside with activity against lymphoproliferative disorders, such as hairy cell leukemia (HCL) and multiple myeloma (MM). 2-CdA resists ADA degradation and is phosphorylated to CdATP in lymphocytes. CdATP incorporation into DNA induces strand breaks and the activation of apoptosis. 2-CdA may also be used in studies involving the inhibition of DNA polymerase(s). Cladribiane, like fludarabine, is a prodrug that is must be phosphorylated intracellularly to the monophosphate by the nuclear/cytosol enzyme deoxycytidine kinase (dCK) and possibly by the mitochondrial enzyme deoxyguanosine kinase (dGK).

ALogP：0.8

IUPAC Name：(2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol

INCHI：InChI=1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1

InChi Key：PTOAARAWEBMLNO-KVQBGUIXSA-N

Canonical SMILES：C1C(C(OC1N2C=NC3=C(N=C(N=C32)Cl)N)CO)O

Isomeric SMILES：C1[C@@H]([C@H](O[C@H]1N2C=NC3=C(N=C(N=C32)Cl)N)CO)O

RTECS：AU7357560

PubChem CID：20279

Reaxy-Rn：624220

DrugBank Ligand：DB00242

CAS Registry No.：4291-63-8

ChEMBL Ligand：CHEMBL1619

Wikipedia：Cladribine

RCSB PDB Ligand：CL9

DrugCentral Ligand：667

溶解性：Soluble in DMSO ( ≥57 mg/ml), water (<1 mg/ml), ethanol (<1 mg/ml), and methanol.

敏感性：对热敏感

熔点：220°C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH301 Toxic if swallowedH311 Toxic in contact with skinH331 Toxic if inhaled

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P361+P364,P264+P265,P301+P316,P337+P317,P332+P317,P316,P319

Merck Index：2337

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