产品名称

英文名称：Sanguinarine chloride hydrate

同义词

SANGUINARINE CHLORIDE、5578-73-4、Sanguinarium Chloride、Viadent、Sanguinarine chloride hydrate、Sanguinarine hydrochloride、Sanguinarine (chloride)、[1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium,13-methyl-, chloride (11)、CHEMBL490129、5578-73-4 (c、氯化血根碱

产品性质

CAS编号：5578-73-4

分子式：C20H14ClNO4 · xH2O

分子量：367.78(anhydrous basis)

MDL号：MFCD00012126

PubChem编号：68635

别名：氯化血根碱

英文别名：SANGUINARINE CHLORIDE|5578-73-4|Sanguinarium Chloride|Viadent|Sanguinarine chloride hydrate|Sanguinarine hydrochloride|Sanguinarine (chloride)|[1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium,13-methyl-, chloride (11)|CHEMBL490129|5578-73-4 (c

规格或纯度：≥97% (HPLC)

英文名称：Sanguinarine chloride hydrate

生化机理：选择性PP2C抑制剂。抑制MKP-1（IC 50 = 10μM）。诱导细胞周期停滞在G 1期。在生长中的细胞中诱导ROS介导的氧化应激。显示抗增殖和细胞毒性作用（SG牙龈上皮细胞的IC 50 = 7.6μM）。

运输条件：常规运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Sanguinarine chloride is a benzophenanthridine alkaloid and potent, noncompetitive sodium/Potassium-ATPase Protein Inhibitors (Na+/K+ ATPase) inhibitor with anticancer properties. This product has been observed to induce apoptosis in cultured C6 rat glioblastoma cells potentially via a downregulative ability of extracellular singal-regulated and Akt signaling pathways. It is reported that sanguinarine also inhibits protein phosphatase 2C (PP2) and induces human promyelocytic leukemia cell line HL60 apoptosis throμgh the phosphorylation of p38, a PP2Cα substrate associated with caspase-3/7 activity. This compound posesses antimicrobial and anti-plaque qualities. Sanguinarine chloride is an inhibitor of MKP-1 and PP2. Isolated from the leaves and stems of Macleaya cordata and M. microcarpa.一个具有抗菌，消炎，抗氧化性能的天然产物。有抑制肿瘤细胞株扩增和促凋亡作用。 A benzophenanthridine alkaloid and potent, noncompetitive Na+/K+-and Mg2++-ATPase inhibitorSanguinarine chloride is a benzophenanthridine alkaloid and potent, noncompetitive sodium/Potassium-ATPase Protein Inhibitors (Na+/K+ ATPase) inhibitor with anticancer properties. This product has been observed to induce apoptosis in cultured C6 rat glioblastoma cells potentially via a downregulative ability of extracellular singal-regulated and Akt signaling pathways. It is reported that sanguinarine also inhibits protein phosphatase 2C (PP2) and induces human promyelocytic leukemia cell line HL60 apoptosis through the phosphorylation of p38, a PP2Cα substrate associated with caspase-3/7 activity. This compound posesses antimicrobial and anti-plaque qualities. Sanguinarine chloride is an inhibitor of MKP-1 and PP2. Isolated from the leaves and stems of Macleaya cordata and M. microcarpa.A benzophenanthridine alkaloid and potent, noncompetitive Na+/K+-and Mg2++-ATPase inhibitor

IUPAC Name：24-methyl-5,7,18,20-tetraoxa-24-azoniahexacyclo[11.11.0.02,10.04,8.014,22.017,21]tetracosa-1(24),2,4(8),9,11,13,15,17(21),22-nonaene;chloride

INCHI：InChI=1S/C20H14NO4.ClH/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21;/h2-8H,9-10H2,1H3;1H/q+1;/p-1

InChi Key：GIZKAXHWLRYMLE-UHFFFAOYSA-M

Canonical SMILES：C[N+]1=C2C(=C3C=CC4=C(C3=C1)OCO4)C=CC5=CC6=C(C=C52)OCO6.[Cl-]

Isomeric SMILES：C[N+]1=C2C(=C3C=CC4=C(C3=C1)OCO4)C=CC5=CC6=C(C=C52)OCO6.[Cl-]

关联CAS：2447-54-3；1099738-80-3

PubChem CID：68635

溶解性：Soluble in methanol, water (slightly), DMSO (10 mM), and ethanol (5 mM).

熔点：277-280°C

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

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