产品名称

英文名称：Amsacrine hydrochloride

同义词

Amsacrine hydrochloride、54301-15-4、m-Amsa hydrochloride、M-Amsacrine、Amsacrine HCl、Amsacrine (hydrochloride)、U66HX4K4CO、DTXSID2037186、NSC 141549、4-(9-Acridinylamino)-N-(methanesulfonyl)-m-anisidine hydrochloride、N-(4-(Acridin-9-ylamino)-3-methoxyphenyl)met、安吖啶,胺苯吖啶

产品性质

CAS编号：54301-15-4

分子式：C21H19N3O3S·HCl

分子量：429.92

MDL号：MFCD07799963

PubChem编号：148673

别名：安吖啶,胺苯吖啶

英文别名：Amsacrine hydrochloride|54301-15-4|m-Amsa hydrochloride|M-Amsacrine|Amsacrine HCl|Amsacrine (hydrochloride)|U66HX4K4CO|DTXSID2037186|NSC 141549|4-(9-Acridinylamino)-N-(methanesulfonyl)-m-anisidine hydrochloride|N-(4-(Acridin-9-ylamino)-3-methoxyphenyl)met

规格或纯度：≥98% (HPLC)

英文名称：Amsacrine hydrochloride

应用：DNA拓扑异构酶II(topoisomerase II) 抑制剂。

运输条件：常规运输

产品介绍：DNA拓扑异构酶II(topoisomerase II) 抑制剂。Product DescribtionAmsacrine hydrochloride is a DNA topoisomerase II inhibitor.Product ApplicationAmsacrine A DNA Intercalator with the Inhibition of Topoisomerase IIAmsacrine (known as m-AMSA) hydrochloride is an acridine derivative that has a potent antitumor activity against leukemic cells. Amsacrine inhibits topoisomerase II which is a group of essential enzymes for DNA replication with important functions for DNA function and cell survival. Topoisomerase II is now viewed as an important cellular target of antitumor drugs including both DNA intercalators (amsacrine and doxorubicin [D4193]) and the nonintercalator epipodophyllotoxin derivatives (etoposide [E0675] and teniposide [T3109]). Amsacrine is often used in combination with other chemotherapy drugs to treat types of adult leukemia, particularly acute myeloid leukemia (AML). (The product is for research purpose only.)

PubChem SID：488188212

IUPAC Name：N-[4-(acridin-9-ylamino)-3-methoxyphenyl]methanesulfonamide;hydrochloride

INCHI：InChI=1S/C21H19N3O3S.ClH/c1-27-20-13-14(24-28(2,25)26)11-12-19(20)23-21-15-7-3-5-9-17(15)22-18-10-6-4-8-16(18)21;/h3-13,24H,1-2H3,(H,22,23);1H

InChi Key：WDISRLXRMMTXEV-UHFFFAOYSA-N

Canonical SMILES：COC1=C(C=CC(=C1)NS(=O)(=O)C)NC2=C3C=CC=CC3=NC4=CC=CC=C42.Cl

Isomeric SMILES：COC1=C(C=CC(=C1)NS(=O)(=O)C)NC2=C3C=CC=CC3=NC4=CC=CC=C42.Cl

WGK Germany：3

RTECS：PB1081000

PubChem CID：148673

UN Number：2811

敏感性：对光敏感

熔点：197-199°C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH301 Toxic if swallowed

预防措施声明：P261,P305+P351+P338,P301+P310

个人防护装备：Eyeshields,Faceshields,Gloves,type P2 (EN 143) respirator cartridges

产品包装