产品名称

英文名称：2,4'-Dibromoacetophenone

同义词

2,4'-Dibromoacetophenone、99-73-0、2-Bromo-1-(4-bromophenyl)ethanone、p-Bromophenacyl bromide、4-Bromophenacyl bromide、Ethanone, 2-bromo-1-(4-bromophenyl)-、2-bromo-1-(4-bromophenyl)-ethanone、2-bromo-1-(4-bromophenyl)ethan-1-one、4'-Bromophenacyl bromide、132309、4-溴苯甲酰甲基溴、4'-溴苯甲酰甲基溴

产品性质

CAS编号：99-73-0

分子式：C8H6Br2O

分子量：277.94

Beilstein号：607604

EC号：202-783-6

MDL号：MFCD00000200

PubChem编号：7454

别名：4-溴苯甲酰甲基溴|4'-溴苯甲酰甲基溴

英文别名：2,4'-Dibromoacetophenone|99-73-0|2-Bromo-1-(4-bromophenyl)ethanone|p-Bromophenacyl bromide|4-Bromophenacyl bromide|Ethanone, 2-bromo-1-(4-bromophenyl)-|2-bromo-1-(4-bromophenyl)-ethanone|2-bromo-1-(4-bromophenyl)ethan-1-one|4'-Bromophenacyl bromide|132309

规格或纯度：98%

英文名称：2,4'-Dibromoacetophenone

应用：A cell-permeable, and non-ATP competitive inhibitor of GSK-3β

储存温度：2-8°C储存,避光

运输条件：冰袋运输

产品介绍：GSK-3β Inhibitor VII is a phenyl α-bromomethyl ketone compound which acts as a cell-permeable, and non-ATP competitive inhibitor of glycogen synthase kinases (GSK-3&beta); (IC = 0.5 μM). This compound acts as an alkylating agent that is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 μM. Research has shown that glycogen synthase kinases have major roles in Wnt and Hedgehog signaling pathways and regulate the cell-division cycle, stem-cell renewal and differentiation, apoptosis, circadian rhythm, transcription and insulin action. This pertinent biological activity makes GSK inhibitors very useful research molecules.A cell-permeable, and non-ATP competitive inhibitor of GSK-3β应用在 SnCl2 或 SmI3 存在的情况下与醛发生缩合反应以生成 α,β-不饱和酮。还用于羧酸的酯化反应。GSK-3β Inhibitor VII is a phenyl α-bromomethyl ketone compound which acts as a cell-permeable, and non-ATP competitive inhibitor of glycogen synthase kinases (GSK-3&beta); (IC = 0.5 μM). This compound acts as an alkylating agent that is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 μM. Research has shown that glycogen synthase kinases have major roles in Wnt and Hedgehog signaling pathways and regulate the cell-division cycle, stem-cell renewal and differentiation, apoptosis, circadian rhythm, transcription and insulin action. This pertinent biological activity makes GSK inhibitors very useful research molecules.A cell-permeable, and non-ATP competitive inhibitor of GSK-3βApplicationUndergoes condensation reactions with aldehydes in the presence of SnCl2 or SmI3 to afford α,β-unsaturated ketones. Also useful in the esterification of carboxylic acids.

IUPAC Name：2-bromo-1-(4-bromophenyl)ethanone

INCHI：InChI=1S/C8H6Br2O/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4H,5H2

InChi Key：FKJSFKCZZIXQIP-UHFFFAOYSA-N

Canonical SMILES：C1=CC(=CC=C1C(=O)CBr)Br

Isomeric SMILES：C1=CC(=CC=C1C(=O)CBr)Br

WGK Germany：2

RTECS：AM6950000

PubChem CID：7454

UN Number：3261

Packing Group：II

Reaxy-Rn：607604

溶解性：Soluble in DMSO (5 mg/ml), methanol (20 mg/ml), toluene, and ethanol. Insoluble in water.

密度：1.848

敏感性：对热和光敏感

熔点：108-110°C

一般危化品：一般危化品

象形图：

信号词：Danger

危险声明：H314 Causes severe skin burns and eye damageH303 May be harmful if swallowed

预防措施声明：P280,P321,P405,P501,P264,P260,P301+P330+P331,P304+P340,P363,P305+P354+P338,P302+P361+P354,P316

Merck Index：1427

产品包装