产品名称

英文名称：Fingolimod HCl

同义词

Fingolimod hydrochloride、162359-56-0、FTY720、Fingolimod HCl、Gilenia、Gilenya、Fty 720、Fty-720、Fingolimod (hydrochloride)、Fingolimod (FTY720) HCl、2-Amino-2-(4-octylphenethyl)propane-1,3-diol hydrochloride、Fingolimod hydrochlorid、FTY720 hydrochloride、2-Amino-2、FTY720、盐酸芬戈莫德、2-氨基-2- [2-(4-辛基-苯基)-乙基]-丙烷-1,3-二醇 盐酸盐

产品性质

CAS编号：162359-56-0

分子式：C19H33NO2·HCl

分子量：343.93

MDL号：MFCD00939512

PubChem编号：107969

别名：FTY720|盐酸芬戈莫德|2-氨基-2- [2-(4-辛基-苯基)-乙基]-丙烷-1,3-二醇 盐酸盐

英文别名：Fingolimod hydrochloride|162359-56-0|FTY720|Fingolimod HCl|Gilenia|Gilenya|Fty 720|Fty-720|Fingolimod (hydrochloride)|Fingolimod (FTY720) HCl|2-Amino-2-(4-octylphenethyl)propane-1,3-diol hydrochloride|Fingolimod hydrochlorid|FTY720 hydrochloride|2-Amino-2

规格或纯度：≥98%

英文名称：Fingolimod HCl

生化机理：FTY720 is an aminopropanediol cell-permeable EDG-1 (endothelial differential gene 1 receptor) antagonist and immunosuppresive agent. It has been shown to display lymphocyte, or white blood cell, sequestration properties. When FTY720 is phosphorylated, it becomes an agonist for four sphingosine 1-phosphate receptors. FTY720 is an inhibitor of cPLA2.Potent agonist at four sphingosine- 1- phosphate (S1P) receptors (S1P 1 , S1P 3 , S1P 4 , and S1P 5 ). Novel immunomodulator able to block T-cell egress from lymph nodes. Structural analog of sphingosine. Orally active in vivo .

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果按照产品小瓶上的说明进行存放，并且小瓶保持紧密密封，则产品最多可存放6个月。如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。

产品介绍：Fingolimod (FTY720) HCl是一种1-磷酸-神经鞘氨醇S1P受体拮抗剂，IC50为0.33 nM。A cell-permeable aminopropanediol immunosuppressive agent that displays lymphocyte sequestration properties.Fingolimod (FTY720) is a S1P antagonist with IC50 of 0.033 nM.A cell-permeable aminopropanediol immunosuppressive agent that displays lymphocyte sequestration properties.

IUPAC Name：2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol;hydrochloride

INCHI：InChI=1S/C19H33NO2.ClH/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22;/h9-12,21-22H,2-8,13-16,20H2,1H3;1H

InChi Key：SWZTYAVBMYWFGS-UHFFFAOYSA-N

Canonical SMILES：CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N.Cl

Isomeric SMILES：CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N.Cl

WGK Germany：3

PubChem CID：107969

溶解性：Soluble in DMSO ( 69 mg/ml) at 25 °C, ethanol (69 mg/ml) at 25 °C, methanol, water (69 mg/ml) at 25 °C, DMF (≥20 mg/ml), and 11 ethanolPBS(pH 7.2) (0.2 mg/ml).

敏感性：对热敏感

熔点：110 °C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH412 Harmful to aquatic life with long lasting effectsH361 Suspected of damaging fertility or the unborn childH362 May cause harm to breast-fed children

预防措施声明：P261,P305+P351+P338,P273,P280,P302+P352,P321,P405,P501,P264,P260,P271,P270,P304+P340,P403+P233,P362+P364,P263,P203,P264+P265,P318,P337+P317,P332+P317,P319

Merck Index：4083

产品包装