产品名称

英文名称：PF-573228

同义词

869288-64-2、PF-573228、PF 573228、PF573228、PF-228、3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone、6-((4-((3-(Methylsulfonyl)benzyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dih

产品性质

CAS编号：869288-64-2

分子式：C22H20F3N5O3S

分子量：491.49

MDL号：MFCD11519967

PubChem编号：11612883

英文别名：869288-64-2|PF-573228|PF 573228|PF573228|PF-228|3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone|6-((4-((3-(Methylsulfonyl)benzyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dih

规格或纯度：≥98%

英文名称：PF-573228

生化机理：PF 573228 is a potent and selective FAK (focal adhesion kinase) inhibitor (IC50 = 4 nM). PF 573228 displays 50-250-fold selectivity over other protein kinases. PF 573228 decreases focal adhesion kinase (FAK) turnover in vitro. PF 573228 also blocks serum and fibronectin-directed migration.Potent and selective FAK inhibitor (IC 50 = 4 nM versus recombunant catalytic fragent). Blocks FAK Tyr397 phosphorylation in cultured cells\xa0(IC 50 = 30–100 n M). Shows\xa050 - 250-fold selectivity for FAK aginst a panel of 40 recombinant kinases.

法律信息：Sold for only research purposes

储存温度：2-8°C储存

运输条件：冰袋运输

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产品介绍：PF-573228是一种ATP竞争性的FAK抑制剂，无细胞试验中IC50为4 nM，作用于FAK比作用于Pyk2，CDK1/7 和 GSK-3β选择性高~50到250倍。A potent and selective FAK (focal adhesion kinase) inhibitor.PF-573228 is an ATP-competitive inhibitor of FAK with IC50 of 4 nM in a cell-free assay, ~50- to 250-fold selective for FAK than Pyk2, CDK1/7 and GSK-3β.A potent and selective FAK (focal adhesion kinase) inhibitor.

IUPAC Name：6-[[4-[(3-methylsulfonylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-quinolin-2-one

INCHI：InChI=1S/C22H20F3N5O3S/c1-34(32,33)16-4-2-3-13(9-16)11-26-20-17(22(23,24)25)12-27-21(30-20)28-15-6-7-18-14(10-15)5-8-19(31)29-18/h2-4,6-7,9-10,12H,5,8,11H2,1H3,(H,29,31)(H2,26,27,28,30)

InChi Key：HESLKTSGTIBHJU-UHFFFAOYSA-N

Canonical SMILES：CS(=O)(=O)C1=CC=CC(=C1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)CC4

Isomeric SMILES：CS(=O)(=O)C1=CC=CC(=C1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)CC4

WGK Germany：3

PubChem CID：11612883

溶解性：Soluble in DMSO (≥20 mg/ml), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C).

象形图：

信号词：Danger

危险声明：H319 Causes serious eye irritationH301 Toxic if swallowed

预防措施声明：P305+P351+P338,P280,P321,P405,P501,P264,P270,P330,P264+P265,P301+P316,P337+P317

产品包装