产品名称

英文名称：Mitoxantrone dihydrochloride

同义词

Mitoxantrone hydrochloride、70476-82-3、Mitoxantrone dihydrochloride、Mitoxantrone HCl、Novantrone、Novantron、Mitoxantrone 2HCl、Mitoxantrone (dihydrochloride)、DHAD、CL-232315、Ralenova、NSC-301739、MITOXANTHRONE HYDROCHLORIDE、Mitozantrone hydrochloride、mitozantron、盐酸米托蒽醌、1,4-二羟基-5,8-双-[[2-[(2-羟乙基)氨基] 乙基] 氨基]-9,10-蒽二酮 二盐酸盐、米托蒽醌二盐酸盐、1,4-二羟基-5,8-双[[2-[(2-羟乙基)氨基]乙基]氨基]蒽醌二盐酸盐、1,4-二羟基-5,8-双[[2-[(2-羟乙基)氨基]乙基]氨基]蒽-9,10-二酮二盐酸盐

产品性质

CAS编号：70476-82-3

分子式：C22H28N4O6·2HCl

分子量：517.4

MDL号：MFCD00242943

PubChem编号：51082

别名：盐酸米托蒽醌|1,4-二羟基-5,8-双-[[2-[(2-羟乙基)氨基] 乙基] 氨基]-9,10-蒽二酮 二盐酸盐|米托蒽醌二盐酸盐|1,4-二羟基-5,8-双[[2-[(2-羟乙基)氨基]乙基]氨基]蒽醌二盐酸盐|1,4-二羟基-5,8-双[[2-[(2-羟乙基)氨基]乙基]氨基]蒽-9,10-二酮二盐酸盐

英文别名：Mitoxantrone hydrochloride|70476-82-3|Mitoxantrone dihydrochloride|Mitoxantrone HCl|Novantrone|Novantron|Mitoxantrone 2HCl|Mitoxantrone (dihydrochloride)|DHAD|CL-232315|Ralenova|NSC-301739|MITOXANTHRONE HYDROCHLORIDE|Mitozantrone hydrochloride|mitozantron

规格或纯度：≥97%

英文名称：Mitoxantrone dihydrochloride

生化机理：Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. Mitoxantrone also displays broad immunosuppressive activity inhibiting proliferation of all classes of lymphocytes and inducing apoptosis of antigen-presenting T cells. It used clinically as a chemotherapeutic agent against leukemias and solid tumors and as an immune system modulator in multiple sclerosis. .Type II topoisomerase inhibitor (IC 50 = 50 nM). Able to inhibit DNA and protein synthesis, and induce both DNA strand breakage and cross linkage. Antineoplastic, immunomodulatory and chemotherapeutic action.

应用：Induces DNA damage by intercalating into DNA and inhibiting Topo II;It can be used to induce calreticulin surface expression in cells， as a genotoxin agent，as a topoisomerase inhibitor.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Mitoxantrone dihydrochloride is an antiviral, antibacterial, antiprotozoal, immunomodulating, and antineoplastic cytostatic anthraquinone derivative. Induces DNA damage by intercalating into DNA and inhibiting Topo II (topoisomerase II). Mitoxantrone dihydrochloride induces interstrand DNA cross-links and DNA-protein cross-links in cellular systems. Mitoxantrone dihydrochloride has recently been shown to be an inhibitor of DNA methylation.Induces DNA damage by intercalating into DNA and inhibiting Topo II;It can be used to induce calreticulin surface expression in cells， as a genotoxin agent，as a topoisomerase inhibitor.Mitoxantrone dihydrochloride is an antiviral, antibacterial, antiprotozoal, immunomodulating, and antineoplastic cytostatic anthraquinone derivative. Induces DNA damage by intercalating into DNA and inhibiting Topo II (topoisomerase II). Mitoxantrone dihydrochloride induces interstrand DNA cross-links and DNA-protein cross-links in cellular systems. Mitoxantrone dihydrochloride has recently been shown to be an inhibitor of DNA methylation.Induces DNA damage by intercalating into DNA and inhibiting Topo II;It can be used to induce calreticulin surface expression in cells， as a genotoxin agent，as a topoisomerase inhibitor.

PubChem SID：488183370

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488183370

IUPAC Name：1,4-dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]anthracene-9,10-dione;dihydrochloride

INCHI：InChI=1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H

InChi Key：ZAHQPTJLOCWVPG-UHFFFAOYSA-N

Canonical SMILES：C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO.Cl.Cl

Isomeric SMILES：C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO.Cl.Cl

关联CAS：65271-80-9

PubChem CID：51082

溶解性：Soluble in water (89 mg/ml at 25 °C), 100% ethanol (slightly), methanol (slightly), and DMSO (89 mg/ml at 25 °C). Insoluble in acetone.

敏感性：对热敏感

熔点：267 °C(dec.)

象形图：

信号词：Danger

危险声明：H360 May damage fertility or the unborn childH340 May cause genetic defects

预防措施声明：P280,P405,P501,P281,P203,P318

Merck Index：6217

产品包装