产品名称

英文名称：Mocetinostat (MGCD0103)

同义词

Mocetinostat、726169-73-9、MGCD0103、MGCD-0103、MGCD 0103、N-(2-AMINOPHENYL)-4-([[4-(PYRIDIN-3-YL)PYRIMIDIN-2-YL]AMINO]METHYL)BENZAMIDE、9003-99-0、N-(2-aminophenyl)-4-[[(4-pyridin-3-ylpyrimidin-2-yl)amino]methyl]benzamide、Mocetinostat (MGCD0103)、Peroxidase、MG01

产品性质

CAS编号：726169-73-9

分子式：C23H20N6O

分子量：396.44

PubChem编号：9865515

英文别名：Mocetinostat|726169-73-9|MGCD0103|MGCD-0103|MGCD 0103|N-(2-AMINOPHENYL)-4-([[4-(PYRIDIN-3-YL)PYRIMIDIN-2-YL]AMINO]METHYL)BENZAMIDE|9003-99-0|N-(2-aminophenyl)-4-[[(4-pyridin-3-ylpyrimidin-2-yl)amino]methyl]benzamide|Mocetinostat (MGCD0103)|Peroxidase|MG01

规格或纯度：≥98%

英文名称：Mocetinostat (MGCD0103)

生化机理：MGCD0103 potently inhibits a subset of the nine human recombinant HDACs, including HDAC1, HDAC2, HDAC3, and HDAC11. MGCD0103 reveals most potent inhibitory activity against human HDAC1 and HDAC2 enzymes in vitro, and it does not inhibit class II HDACs. The inhibitory activity of MGCD0103 reaches the maximum plateau at 6 μM, and the maximal inhibitable enzyme pool affected by MGCD0103 is 75% of the total enzyme activity in HCT116 cells.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：Mocetinostat (MGCD0103)是一种有效的HDAC抑制剂，对HDAC1抑制作用最强，IC50为0.15 μM，比作用于HDAC2， 3，和11选择性高2到10倍，对HDAC4， 5， 6， 7，和8没有抑制活性。Phase 2。A potent inhibitor of HDAC1, HDAC2, HDAC3, and HDAC11.Mocetinostat (MGCD0103) is a potent HDAC inhibitor with most potency for HDAC1 with IC50 of 0.15 μM, 2- to 10- fold selectivity against HDAC2, 3, and 11, and no activity to HDAC4, 5, 6, 7, and 8. Phase 2.A potent inhibitor of HDAC1, HDAC2, HDAC3, and HDAC11.

ALogP：2.8

IUPAC Name：N-(2-aminophenyl)-4-[[(4-pyridin-3-ylpyrimidin-2-yl)amino]methyl]benzamide

INCHI：InChI=1S/C23H20N6O/c24-19-5-1-2-6-21(19)28-22(30)17-9-7-16(8-10-17)14-27-23-26-13-11-20(29-23)18-4-3-12-25-15-18/h1-13,15H,14,24H2,(H,28,30)(H,26,27,29)

InChi Key：HRNLUBSXIHFDHP-UHFFFAOYSA-N

Canonical SMILES：C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC3=NC=CC(=N3)C4=CN=CC=C4

Isomeric SMILES：C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC3=NC=CC(=N3)C4=CN=CC=C4

PubChem CID：9865515

CAS Registry No.：726169-73-9

ChEMBL Ligand：CHEMBL272980

Wikipedia：Mocetinostat

溶解性：DMSO 13 mg/mL (32.79 mM); Water <1 mg/mL (<1 mM); Ethanol <1 mg/mL (<1 mM)

产品包装