产品名称

英文名称：Pazopanib HCl (GW786034 HCl)

同义词

Pazopanib hydrochloride、635702-64-6、pazopanib HCl、Votrient、Pazopanib (Hydrochloride)、Armala、UNII-33Y9ANM545、pazopanib monohydrochloride、Pazopanib HCl (GW786034 HCl)、GW786034B、Pazopanib (as hydrochloride)、CHEBI71217、33Y9ANM545、GW-786034B、GW786034 (Hydroch、盐酸帕唑帕尼

产品性质

CAS编号：635702-64-6

分子式：C21H23N7O2S·HCl

分子量：473.98

MDL号：MFCD12546138

PubChem编号：11525740

别名：盐酸帕唑帕尼

英文别名：Pazopanib hydrochloride|635702-64-6|pazopanib HCl|Votrient|Pazopanib (Hydrochloride)|Armala|UNII-33Y9ANM545|pazopanib monohydrochloride|Pazopanib HCl (GW786034 HCl)|GW786034B|Pazopanib (as hydrochloride)|CHEBI71217|33Y9ANM545|GW-786034B|GW786034 (Hydroch

规格或纯度：≥98%

英文名称：Pazopanib HCl (GW786034 HCl)

生化机理：Pazopanib Hydrochloride (GW786034, Votrient, Armala) is a novel, multitargeted inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR, FGFR, c-Kit and c-fms with IC50 values of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：25mg卖完停产，不再备货

产品介绍：Pazopanib HCl (GW786034 HCl)是一种新型的针对VEGFR-1， VEGFR-2， VEGFR-3， PDGFR， FGFR， c-Kit和c-fms等多个靶点的抑制剂，IC50分别是10 nM， 30 nM， 47 nM， 84 nM， 74 nM， 140 nM和146 nM。A multi-targeted inhibitor.Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively.A multi-targeted inhibitor.

IUPAC Name：5-[[4-[(2,3-dimethylindazol-6-yl)-methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide;hydrochloride

INCHI：InChI=1S/C21H23N7O2S.ClH/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16;/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25);1H

InChi Key：MQHIQUBXFFAOMK-UHFFFAOYSA-N

Canonical SMILES：CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N.Cl

Isomeric SMILES：CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N.Cl

PubChem CID：11525740

溶解性：Soluble in DMSO (17 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), and 30% PEG400/0.5% Tween80/5% propylene glycol (30 mg/ml at 25 °C).

敏感性：对空气敏感、吸湿、对热敏感

象形图：

信号词：Danger

危险声明：H351 Suspected of causing cancerH411 Toxic to aquatic life with long lasting effectsH400 Very toxic to aquatic lifeH372 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn childH361 Suspected of damaging fertility or the unborn child

预防措施声明：P273,P280,P405,P501,P264,P260,P270,P391,P203,P318,P319

产品包装