产品名称

英文名称：PP121

同义词

PP121、1092788-83-4、1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine、PP-121、PP 121、1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyrazolo[3,4-d]pyrimidin-4-amine、CHEMBL1081312、CHEBI50915、1H-Pyrazolo[3,4-d]pyrimidin-4-am

产品性质

CAS编号：1092788-83-4

分子式：C17H17N7

分子量：319.36

MDL号：MFCD12912434

PubChem编号：24905142

英文别名：PP121|1092788-83-4|1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine|PP-121|PP 121|1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyrazolo[3,4-d]pyrimidin-4-amine|CHEMBL1081312|CHEBI50915|1H-Pyrazolo[3,4-d]pyrimidin-4-am

规格或纯度：≥98%

英文名称：PP121

生化机理：PP121 has been shown to be an inhibitor of tyrosine and phosphoinositide kinases. PP121 inhibits c-Abl (IC50 of 18 nM), PI 3-kinase (IC50 of < 0.06 μM), PDGFR (IC50 of 2 nM), Hck (IC50 of 8 nM), FRAP (IC50 of 10 nM), Flk-1 (IC50 of 12 nM), SRC (IC50 of 14 nM), and DNA-PK (IC50 of < 0.06 μM). PP121 does not affect other serine-threonine protein kinases. PP-121 potently inhibits the proliferation of a subset of tumor cell lines by direct inhibition of PI 3-kinase and FRAP.PP121 is a dual inhibitor of tyrosine (C 50 < 0.02 μ M for Abl, Src, VEGFR-2 and PDGFR) and phosphoinositide kinases (IC 50 < 0.06 μ M for p110 α , DNA-PK and mTOR). Blocks the proliferation of tumor cells by direct inhibition of PI 3-K, mTOR, Src and the

储存温度：2-8°C储存

运输条件：冰袋运输

备注：有关更多信息，请参阅SDS。有关溶解度，用法和处理的更多建议？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：PP121是一种作用于PDGFR， Hck， mTOR， VEGFR2， Src和Abl的多靶点抑制剂，IC50分别为2 nM， 8 nM， 10 nM， 12 nM， 14 nM和18 nM，也抑制DNA-PK，IC50为60 nM。An inhibitor of c-Abl, PI 3-kinase, PDGFR, Hck, FRAP, Flk-1, SRC, and DNA-PK.PP-121 is a multi-targeted inhibitor of PDGFR, Hck, mTOR, VEGFR2, Src and Abl with IC50 of 2 nM, 8 nM, 10 nM, 12 nM, 14 nM and 18 nM, also inhibits DNA-PK with IC50 of 60 nM.An inhibitor of c-Abl, PI 3-kinase, PDGFR, Hck, FRAP, Flk-1, SRC, and DNA-PK.

IUPAC Name：1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyrazolo[3,4-d]pyrimidin-4-amine

INCHI：InChI=1S/C17H17N7/c18-15-13-14(11-7-10-5-6-19-16(10)20-8-11)23-24(12-3-1-2-4-12)17(13)22-9-21-15/h5-9,12H,1-4H2,(H,19,20)(H2,18,21,22)

InChi Key：NVRXTLZYXZNATH-UHFFFAOYSA-N

Canonical SMILES：C1CCC(C1)N2C3=NC=NC(=C3C(=N2)C4=CN=C5C(=C4)C=CN5)N

Isomeric SMILES：C1CCC(C1)N2C3=NC=NC(=C3C(=N2)C4=CN=C5C(=C4)C=CN5)N

WGK Germany：1

PubChem CID：24905142

CAS Registry No.：1092788-83-4

DrugBank Ligand：DB08052

ChEMBL Ligand：CHEMBL1081312

ChEBI：CHEBI50915

RCSB PDB Ligand：KS1, 9HE

溶解性：Soluble in DMSO (64 mg/mL at 25 °C), water (<1 mg/mL at 25 °C), and ethanol (2 mg/mL at 25 °C).

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

产品包装