产品名称

英文名称：Cabazitaxel

同义词

CABAZITAXEL、183133-96-2、Jevtana、Taxoid XRP6258、Cabazitaxelum、XRP-6258、Xrp6258、kabazitaxel、TXD 258、Jevtana Kit、Cabazitaxel Injection、Jevanta、XRP 6258、NSC-761432、TXD258、CHEBI63584、UNII-51F690397J、RPR 116258A、RPR-116258A、Jevtana (TN)、51F690397J、DTXSID401713、卡巴他赛、7β,10β-二甲氧基多西紫杉醇

产品性质

CAS编号：183133-96-2

分子式：C45H57NO14

分子量：835.93

MDL号：MFCD18827611

PubChem编号：9854073

别名：卡巴他赛|7β,10β-二甲氧基多西紫杉醇

英文别名：CABAZITAXEL|183133-96-2|Jevtana|Taxoid XRP6258|Cabazitaxelum|XRP-6258|Xrp6258|kabazitaxel|TXD 258|Jevtana Kit|Cabazitaxel Injection|Jevanta|XRP 6258|NSC-761432|TXD258|CHEBI63584|UNII-51F690397J|RPR 116258A|RPR-116258A|Jevtana (TN)|51F690397J|DTXSID401713

规格或纯度：≥99%

英文名称：Cabazitaxel

生化机理：Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrμg resistance (MDR), P-glycoprotein (P-gp) efflux pump and may be useful for treating multidrμg-resistant tumors. In addition, cabazitaxel penetrates the blood-brain barrier (BBB).

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：50mg、250mg、10mg卖完停产，不再备货

产品介绍：Cabazitaxel (RPR-116258A, XRP6258, TXD 258, Taxoid XRP6258)是一种天然紫杉烷的半合成衍生物，能够抑制细胞分裂和生长，从而杀死癌细胞。抑制微管生长和聚合。Cabazitaxel 可通过PI3K/Akt/mTOR信号通路诱导自噬。Cabazitaxel (XRP6258) is a semi-synthetic derivative of a natural taxoid

ALogP：2.7

IUPAC Name：[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-1-hydroxy-15-[(2R,3S)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]oxy-9,12-dimethoxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate

INCHI：InChI=1S/C45H57NO14/c1-24-28(57-39(51)33(48)32(26-17-13-11-14-18-26)46-40(52)60-41(3,4)5)22-45(53)37(58-38(50)27-19-15-12-16-20-27)35-43(8,36(49)34(55-10)31(24)42(45,6)7)29(54-9)21-30-44(35,23-56-30)59-25(2)47/h11-20,28-30,32-35,37,48,53H,21-23H2,1-10H3,(H,46,52)/t28-,29-,30+,32-,33+,34+,35-,37-,43+,44-,45+/m0/s1

InChi Key：BMQGVNUXMIRLCK-OAGWZNDDSA-N

Canonical SMILES：CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)OC)C)OC

Isomeric SMILES：CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)OC)C)OC

PubChem CID：9854073

DrugBank Ligand：DB06772

CAS Registry No.：183133-96-2

ChEMBL Ligand：CHEMBL1201748

Wikipedia：Cabazitaxel

PEP：cabaitaxel

DrugCentral Ligand：4153

溶解性：DMSO > 125 mg/ml

熔点：180°C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH335 May cause respiratory irritationH311 Toxic in contact with skinH341 Suspected of causing genetic defectsH373 Causes damage to organs through prolonged or repeated exposureH302 Harmful if swallowedH318 Causes serious eye damageH317 May cause an allergic skin reactionH400 Very toxic to aquatic lifeH410 Very toxic to aquatic life with long lasting effectsH372 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn childH361 Suspected of damaging fertility or the unborn childH362 May cause harm to breast-fed children

预防措施声明：P261,P273,P280,P302+P352,P321,P405,P501,P264,P260,P281,P271,P270,P304+P340,P403+P233,P272,P333+P313,P362+P364,P391,P330,P263,P361+P364,P203,P264+P265,P301+P317,P305+P354+P338,P318,P317,P332+P317,P316,P319

产品包装