产品名称

英文名称：UPF 1069

同义词

UPF 1069、1048371-03-4、UPF-1069、5-(2-Oxo-2-phenylethoxy)isoquinolin-1(2H)-one、5-Phenacyloxy-2H-isoquinolin-1-one、CHEMBL4089840、UPF1069、5-(2-oxo-2-phenylethoxy)-1(2H)-Isoquinolinone、SCHEMBL18548812、DTXSID40648425、EX-A287、HMS3414B17、HMS3653L04、HMS3678B17、BCP

产品性质

CAS编号：1048371-03-4

分子式：C17H13NO3

分子量：279.29

PubChem编号：25015515

英文别名：UPF 1069|1048371-03-4|UPF-1069|5-(2-Oxo-2-phenylethoxy)isoquinolin-1(2H)-one|5-Phenacyloxy-2H-isoquinolin-1-one|CHEMBL4089840|UPF1069|5-(2-oxo-2-phenylethoxy)-1(2H)-Isoquinolinone|SCHEMBL18548812|DTXSID40648425|EX-A287|HMS3414B17|HMS3653L04|HMS3678B17|BCP

规格或纯度：≥98%

英文名称：UPF 1069

生化机理：In organotypic hippocampal slices, PARP-2 inhibition with UPF-1069 (0.01-1 micromolxL(-1)) caused a concentration-dependent exacerbation (up to 155%) of OGD-induced CA1 pyramidal cell death. Higher concentrations, acting on both PARP-1 and PARP-2, had no effect on OGD injury.Selective PARP2 inhibitor (IC 50 = 0.3 μM). Induces apoptosis. Shows neurprotective and anti-ischemic effects in vivo.

储存温度：-20°C储存

运输条件：超低温冰袋运输

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产品介绍：UPF 1069是PARP2选择性抑制剂，IC50为0.3 μM，比对PARP1的抑制性高27倍。A selective poly(ADP-ribose) polymerase (PARP) 2 inhibitor.UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM. It is ~27-fold selective against PARP1.A selective poly(ADP-ribose) polymerase (PARP) 2 inhibitor.

IUPAC Name：5-phenacyloxy-2H-isoquinolin-1-one

INCHI：InChI=1S/C17H13NO3/c19-15(12-5-2-1-3-6-12)11-21-16-8-4-7-14-13(16)9-10-18-17(14)20/h1-10H,11H2,(H,18,20)

InChi Key：JJWMRRNGWSITSQ-UHFFFAOYSA-N

Canonical SMILES：C1=CC=C(C=C1)C(=O)COC2=CC=CC3=C2C=CNC3=O

Isomeric SMILES：C1=CC=C(C=C1)C(=O)COC2=CC=CC3=C2C=CNC3=O

PubChem CID：25015515

溶解性：DMSO 56 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

密度：1.3

折光率：1.62

沸点：~570.3 °C at 760 mmHg

熔点：166-168°C

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

产品包装