产品名称

英文名称：[Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt

同义词

Melanotan I、Melanotan-1、4-Nle-7-phe-alpha-msh、NDP-alpha-MSH、CUV1647、CUV 1647、CUV-1647、QW68W3J66U、scenesse、(Nle4,D-Phe7)-alpha-MSH、[Nle4,D-Phe7]-alpha-MSH、Melanotan-I、AC-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2、Msh, 4-nle-7-phe-alpha-、Afam

产品性质

CAS编号：75921-69-6

分子式：C78H111N21O19

分子量：1646.85

MDL号：MFCD03788203

PubChem编号：16154396

英文别名：Melanotan I|Melanotan-1|4-Nle-7-phe-alpha-msh|NDP-alpha-MSH|CUV1647|CUV 1647|CUV-1647|QW68W3J66U|scenesse|(Nle4,D-Phe7)-alpha-MSH|[Nle4,D-Phe7]-alpha-MSH|Melanotan-I|AC-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2|Msh, 4-nle-7-phe-alpha-|Afam

规格或纯度：≥95% (HPLC)

英文名称：[Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt

生化机理：α-MSH的合成类似物，它是对黑皮质素受体的激动剂（MC1，MC3，MC4和MC5受体的Ki值分别为0.085、0.4、3.8和5.1 nM）。

应用：[Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt has been used to detect its effect on O2 consumption and CO2 production in C57BL/6 mice.1It is also used to determine its effect on leptin secretion in the primary cultures of differentiated adipocytes.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：1mg卖完停产，不再备货

产品介绍：Amino Acid Sequence Ac-Ser-Tyr-Ser-Nle-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2[Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt has been used to detect its effect on O2 consumption and CO2 production in C57BL/6 mice.1It is also used to determine its effect on leptin secretion in the primary cultures of differentiated adipocytes.Amino Acid Sequence Ac-Ser-Tyr-Ser-Nle-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2

IUPAC Name：(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]-5-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-6-amino-1-[(2S)-2-[[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-2-oxoethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid

INCHI：InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61-,62-,65-/m0/s1

InChi Key：UAHFGYDRQSXQEB-LEBBXHLNSA-N

Canonical SMILES：CCCCC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CNC=N1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NCC(=O)NC(CCCCN)C(=O)N5CCCC5C(=O)NC(C(C)C)C(=O)N)NC(=O)C(CO)NC(=O)C(CC6=CC=C(C=C6)O)NC(=O)C(CO)NC(=O)C

Isomeric SMILES：CCCC[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@H](CC2=CC=CC=C2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC3=CNC4=CC=CC=C43)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N5CCC[C@H]5C(=O)N[C@@H](C(C)C)C(=O)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC6=CC=C(C=C6)O)NC(=O)[C@H](CO)NC(=O)C

PubChem CID：16154396

CAS Registry No.：75921-69-6

Wikipedia：Afamelanotide

GPCRdb Ligand：afamelanotide

溶解性：Soluble to 0.60 (mg/mL) in water}

产品包装