产品名称

英文名称：KRN-633

同义词

KRN-633、286370-15-8、KRN 633、KRN633、K00589a、VEGF receptor tyrosine kinase inhibitor III、1-(2-chloro-4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-propylurea、CHEMBL406381、1-{2-chloro-4-[(6,7-dimethoxyquinazolin-4-yl)oxy]phenyl}-3-propylurea、E1V875I8DX、VEGFR

产品性质

CAS编号：286370-15-8

分子式：C20H21ClN4O4

分子量：416.87

PubChem编号：9549295

英文别名：KRN-633|286370-15-8|KRN 633|KRN633|K00589a|VEGF receptor tyrosine kinase inhibitor III|1-(2-chloro-4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-propylurea|CHEMBL406381|1-{2-chloro-4-[(6,7-dimethoxyquinazolin-4-yl)oxy]phenyl}-3-propylurea|E1V875I8DX|VEGFR

规格或纯度：≥97%

英文名称：KRN-633

生化机理：KRN633 is a cell-permeable; reversible and ATP-competitive inhibitor of vascular endothelial growth factor receptor tyrosine kinase (VEGFR) with IC50 values of 170, 160, and 125 nM for VEGFR-1, -2, -3, respectively. Krn633 inhibits PDGFR-α and c-Kit only at higher concentrations (IC50 = 0.97 and 4.33 μM, respectively) and is inactive towards a panel of 17 other kinases (IC50 >/= 10 μM).

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：KRN-633是可渗透细胞的，可逆的。ATP竞争性VEGFR抑制剂，对VEGFR-1，VEGFR-2和VEGFR-3的IC50分别为170 nM，160 nM和125 nM。An ATP-competitive inhibitor of VEGFR (Flt and Flk) kinaseKRN-633 is a cell-permeable, reversible, ATP-competitive VEGFR kinase inhibitor with IC50 of 170 nM, 160 nM, and 125 nM for VEGFR-1, VEGFR-2, VEGFR-3, respectively.An ATP-competitive inhibitor of VEGFR (Flt and Flk) kinase

ALogP：3.9

IUPAC Name：1-[2-chloro-4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-3-propylurea

INCHI：InChI=1S/C20H21ClN4O4/c1-4-7-22-20(26)25-15-6-5-12(8-14(15)21)29-19-13-9-17(27-2)18(28-3)10-16(13)23-11-24-19/h5-6,8-11H,4,7H2,1-3H3,(H2,22,25,26)

InChi Key：VPBYZLCHOKSGRX-UHFFFAOYSA-N

Canonical SMILES：CCCNC(=O)NC1=C(C=C(C=C1)OC2=NC=NC3=CC(=C(C=C32)OC)OC)Cl

Isomeric SMILES：CCCNC(=O)NC1=C(C=C(C=C1)OC2=NC=NC3=CC(=C(C=C32)OC)OC)Cl

WGK Germany：3

PubChem CID：9549295

ChEMBL Ligand：CHEMBL406381

CAS Registry No.：286370-15-8

溶解性：DMSO ≥8mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

产品包装