产品名称

英文名称：Dexamethasone

同义词

Dexadeltone 、 OTO-104 、 Decasone 、 Hexadrol Tablets 、 Dexametasone 、 Dexameth 、 Dexinolon 、 Dexinoral 、 (3H)-Dexamethasone 、 Decacortin 、 Dexametasona 、 Dex-ide 、 Mexidex 、 Pet Derm III 、 Adexone 、 Dexamonozon 、 Dexone 0.5 、 Lokalison F 、 Ocu-trol 、 Aphta、德沙美松 、 21α-乙酰氧基-9α-氟-11β,17α-二羟基-16α-甲基孕甾-1,4-二烯-3,20-二酮 、 9α-氟-16α-甲基氢化泼尼松 、 9-氟-11,17,21-三羟基-16-甲基(11b,16a)-孕甾-1,4-二烯-3,20-二酮 、 泼尼松龙F 、 9α-氟-16α-甲基-11β,17α,21-三羟基-1,4-妊娠双烯-3,20-二酮 、 (11β,16α)-9-氟-11,17,21-三羟基-16-甲基孕甾-1,4-二烯-3,20-二酮

产品性质

CAS编号：50-02-2

分子式：C22H29FO5

分子量：392.46

Beilstein号：2066651

EC号：200-003-9

MDL号：MFCD00064136

PubChem编号：5743

别名：德沙美松 | 21α-乙酰氧基-9α-氟-11β,17α-二羟基-16α-甲基孕甾-1,4-二烯-3,20-二酮 | 9α-氟-16α-甲基氢化泼尼松 | 9-氟-11,17,21-三羟基-16-甲基(11b,16a)-孕甾-1,4-二烯-3,20-二酮 | 泼尼松龙F | 9α-氟-16α-甲基-11β,17α,21-三羟基-1,4-妊娠双烯-3,20-二酮 | (11β,16α)-9-氟-11,17,21-三羟基-16-甲基孕甾-1,4-二烯-3,20-二酮

英文别名：Dexadeltone | OTO-104 | Decasone | Hexadrol Tablets | Dexametasone | Dexameth | Dexinolon | Dexinoral | (3H)-Dexamethasone | Decacortin | Dexametasona | Dex-ide | Mexidex | Pet Derm III | Adexone | Dexamonozon | Dexone 0.5 | Lokalison F | Ocu-trol | Aphta

规格或纯度：98%

英文名称：Dexamethasone

生化机理：Dexamethasone is an antiinflammatory glucocorticoid that induces the production of phospholipase A2 inhibitory protein (lipocortin). It also inhibits induction of nitric oxide synthase (IC50=5 nM). Dexamethasone has been shown to cause reduction in cyclin A and Cdk2 activity, inhibition of G1/S transition in osteoblasts and inhibition of phosphorylation of Rb protein. Dexamethasone has been observed to induce apoptosis in human thymocytes and eosinophils, but inhibits apoptosis in neutrophils. Dexamethasone is an activator of IDO.Anti-inflammatory glucocorticoid (IC 50 = 38 nM and K i = 6.7 nM for the glucocorticoid receptor). Displays 7-fold higher affinity for glucocorticoid receptors than hydrocortisone. Long-term effects following oral administration.

储存温度：2-8°C储存,充氩

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：An antiinflammatory glucocorticoidDexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.An antiinflammatory glucocorticoid

ALogP：1.9

PubChem SID：488179921

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488179921

IUPAC Name：(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

INCHI：InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

InChi Key：UREBDLICKHMUKA-CXSFZGCWSA-N

Canonical SMILES：CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C

Isomeric SMILES：C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C

WGK Germany：2

RTECS：TU3980000

关联CAS：23495-06-9,50-02-2

PubChem CID：5743

NSC Number：34521

MeSH Entry Terms：Decaject;Decaject L.A.;Decaject-L.A.;Decameth;Decaspray;Dexamethasone;Dexasone;Dexpak;Hexadecadrol;Hexadrol;Maxidex;Methylfluorprednisolone;Millicorten;Oradexon

溶解性：Soluble in ethanol (25 mg/ml), and DMSO (25 mg/ml). Insoluble in water.

敏感性：对光线和空气敏感

熔点：262-264°C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH373 Causes damage to organs through prolonged or repeated exposureH317 May cause an allergic skin reactionH334 May cause allergy or asthma symptoms or breathing difficulties if inhaledH410 Very toxic to aquatic life with long lasting effectsH360 May damage fertility or the unborn childH361 Suspected of damaging fertility or the unborn child

预防措施声明：P261,P305+P351+P338,P273,P280,P302+P352,P321,P405,P501,P264,P260,P284,P271,P304+P340,P403+P233,P272,P333+P313,P362+P364,P391,P203,P264+P265,P318,P337+P317,P332+P317,P319,P342+P316

产品包装