产品名称

英文名称：IQ-1

同义词

IQ-1、331001-62-8、(2Z)-2-[(4-acetylphenyl)hydrazinylidene]-2-(3,3-dimethyl-4H-isoquinolin-1-yl)acetamide、IQ 1、2-((4-Acetylphenyl)diazenyl)-2-(3,3-dimethyl-3,4-dihydroisoquinolin-1(2H)-ylidene)acetamide、acetamide,2-(2-(4-acetylphenyl)diazenyl)-2-(3,4-dihydr

产品性质

CAS编号：331001-62-8

分子式：C21H22N4O2

分子量：362.42

PubChem编号：5721207

英文别名：IQ-1|331001-62-8|(2Z)-2-[(4-acetylphenyl)hydrazinylidene]-2-(3,3-dimethyl-4H-isoquinolin-1-yl)acetamide|IQ 1|2-((4-Acetylphenyl)diazenyl)-2-(3,3-dimethyl-3,4-dihydroisoquinolin-1(2H)-ylidene)acetamide|acetamide,2-(2-(4-acetylphenyl)diazenyl)-2-(3,4-dihydr

规格或纯度：95% (HPLC)

英文名称：IQ-1

生化机理：IQ-1 enhances β-catenin/CBP interactions and blocks β-catenin/p300 driven transcription, which enables mouse embryonic stem cells (ESCs) to be maintained in an undifferentiated pluripotent state, allowing expansion and self-renewal of mouse ESC populations.Cell-permeable Wnt pathway activator. Targets PR72/130 subunit of PP2A. Maintains ESC pluripotency when co-administered with Wnt3a in vitro . Active in vivo .

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：IQ-1可以使小鼠胚胎干细胞在Wnt/β-catenin信号的驱使下扩增并阻止其非定向分化。在经Wnt3a处理的细胞中，维持维持胚胎干细胞(ESC)多能性、阻止PP2A/Nkd的相互作用。Q 1 has many functions such as decreasing Wnt-stimulated phosphorylation, maintaining the pluripotency of murine ESCs, preventing PP2A/Nkd interaction and so on. IQ 1 maintains the pluripotency of murine ESCs in long-term culture in a Wnt-dependent manner. IQ 1 decreased Wnt-stimulated phosphorylation of p300 at Ser-89.IQ-1 binds to serine/threonine phosphatase PP2A and prevents PP2A/Nkd interaction.The binding of IQ 1 to PR72/130 leads to decreased phosphorylation of the coactivator protein p300 at Ser-89. IQ 1 thereby diminishes the β-catenin/p300 interaction and prevents β-catenin coactivator switching from CBP to p300.

IUPAC Name：(2Z)-2-[(4-acetylphenyl)hydrazinylidene]-2-(3,3-dimethyl-4H-isoquinolin-1-yl)acetamide

INCHI：InChI=1S/C21H22N4O2/c1-13(26)14-8-10-16(11-9-14)24-25-19(20(22)27)18-17-7-5-4-6-15(17)12-21(2,3)23-18/h4-11,24H,12H2,1-3H3,(H2,22,27)/b25-19-

InChi Key：ALJIEVIJBAJISI-PLRJNAJWSA-N

Canonical SMILES：CC(=O)C1=CC=C(C=C1)NN=C(C2=NC(CC3=CC=CC=C32)(C)C)C(=O)N

Isomeric SMILES：CC(=O)C1=CC=C(C=C1)N/N=C(/C2=NC(CC3=CC=CC=C32)(C)C)\C(=O)N

PubChem CID：5721207

溶解性：solubility DMSO 10 mg/mL, clear;Ethanol 7 mg/mL Insoluble in water

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

产品包装