产品名称

英文名称：ABC294640

同义词

ABC294640、Opaganib、915385-81-8、ABC-294640、3-(4-chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide、ABC 294640、CHEMBL2158685、Yeliva、ABC294640Opaganib、OPAGANIB [INN]、OPAGANIB [WHO-DD]、Opaganib (ABC294640)、GTPL6624、SCHEMBL1548333、CHEBI124965、DTXSID

产品性质

CAS编号：915385-81-8

分子式：C23H25ClN2O

分子量：380.91

PubChem编号：15604015

英文别名：ABC294640|Opaganib|915385-81-8|ABC-294640|3-(4-chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide|ABC 294640|CHEMBL2158685|Yeliva|ABC294640Opaganib|OPAGANIB [INN]|OPAGANIB [WHO-DD]|Opaganib (ABC294640)|GTPL6624|SCHEMBL1548333|CHEBI124965|DTXSID

规格或纯度：98%

英文名称：ABC294640

生化机理：ABC294640 is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon administration, ABC294640 competitively binds to and inhibits SK2, thereby preventing the phosphorylation of the pro-apoptotic amino alcohol sphingosine to sphingosine 1-phosphate (S1P), the lipid mediator that is pro-survival and critical for immunomodulation. This may eventually lead to the induction of apoptosis and may result in an inhibition of cell proliferation in cancer cells overexpressing SK2. SK2 and its isoenzyme SK1 are overexpressed in numerous cancer cell types.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Opaganib (ABC294640)是一种选择性sphingosine kinase-2 (SphK2)抑制剂，IC50约为 60 μM

ALogP：4.7

IUPAC Name：3-(4-chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide

INCHI：InChI=1S/C23H25ClN2O/c24-20-3-1-19(2-4-20)22-10-17-9-18(11-22)13-23(12-17,15-22)21(27)26-14-16-5-7-25-8-6-16/h1-8,17-18H,9-15H2,(H,26,27)

InChi Key：CAOTVXGYTWCKQE-UHFFFAOYSA-N

Canonical SMILES：C1C2CC3(CC1CC(C2)(C3)C(=O)NCC4=CC=NC=C4)C5=CC=C(C=C5)Cl

Isomeric SMILES：C1C2CC3(CC1CC(C2)(C3)C(=O)NCC4=CC=NC=C4)C5=CC=C(C=C5)Cl

PubChem CID：15604015

CAS Registry No.：915385-81-8

ChEMBL Ligand：CHEMBL2158685

溶解性：≥38.1 mg/mL in DMSO; insoluble in H2O; ≥58.9 mg/mL in EtOH

产品包装