产品名称

英文名称：BMS-927711

同义词

Rimegepant、1289023-67-1、BMS-927711、BMS 927711、BHV-3000、BMS927711、UNII-997WVV895X、997WVV895X、BMS-927711(Rimegepant)、CHEMBL2178422、BHV3000、DTXSID70156003、(5S,6S,9R)-5-Amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-

产品性质

CAS编号：1289023-67-1

分子式：C28H28F2N6O3

分子量：534.56

EC号：822-372-0

PubChem编号：51049968

英文别名：Rimegepant|1289023-67-1|BMS-927711|BMS 927711|BHV-3000|BMS927711|UNII-997WVV895X|997WVV895X|BMS-927711(Rimegepant)|CHEMBL2178422|BHV3000|DTXSID70156003|(5S,6S,9R)-5-Amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-

规格或纯度：98%

英文名称：BMS-927711

生化机理：Calcitonin gene-related peptide (CGRP) is closely involved in the cascade of molecular events leading to migraine painful crisis. New CGRP-R antagonist, such as BMS-927711, is in the pipeline and its developments will outline the future of this drμg class. BMS-927711 has good oral bioavailability in rat and cynomolgus monkey, attractive overall preclinical properties, and shows dose-dependent activity in a primate model of CGRP-induced facial blood flow. BMS-927711 is presently in phase II clinical trials.

储存温度：避光,-20°C储存

运输条件：超低温冰袋运输

产品介绍：产品介绍Rimegepant (BMS-927711, BHV-3000)是一种选择性的、竞争性的人降钙素基因相关肽(CGRP)受体拮抗剂，Ki为0.027 nM。

ALogP：2.3

IUPAC Name：[(5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl] 4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate

INCHI：InChI=1S/C28H28F2N6O3/c29-20-6-1-4-17(23(20)30)18-8-9-22(25-19(24(18)31)5-2-12-32-25)39-28(38)35-14-10-16(11-15-35)36-21-7-3-13-33-26(21)34-27(36)37/h1-7,12-13,16,18,22,24H,8-11,14-15,31H2,(H,33,34,37)/t18-,22+,24-/m0/s1

InChi Key：KRNAOFGYEFKHPB-ANJVHQHFSA-N

Canonical SMILES：C1CC(C2=C(C=CC=N2)C(C1C3=C(C(=CC=C3)F)F)N)OC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6

Isomeric SMILES：C1C[C@H](C2=C(C=CC=N2)[C@H]([C@@H]1C3=C(C(=CC=C3)F)F)N)OC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6

关联CAS：1374024-48-2,1289023-67-1

PubChem CID：51049968

MeSH Entry Terms：(5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta(b)pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo(4,5-b)pyridin-1-yl)piperidine-1-carboxylate;BMS-927711;Nurtec ODT;rimegepant;rimegepant sulfate

CAS Registry No.：1289023-67-1

ChEMBL Ligand：CHEMBL2178422

BindingDB Ligand：50400098

DrugBank Ligand：DB12457

DrugCentral Ligand：5381

溶解性：DMSO

敏感性：对光线敏感

象形图：

信号词：Warning

危险声明：H373 Causes damage to organs through prolonged or repeated exposureH361 Suspected of damaging fertility or the unborn childH361d Suspected of damaging the unborn child

预防措施声明：P280,P405,P501,P260,P203,P318,P319

产品包装