产品名称

英文名称：Pinometostat (EPZ5676)

同义词

pinometostat、1380288-87-8、EPZ-5676、EPZ5676、Pinometostat, trans-、Pinometostat [INN]、Pinometostat anhydrous、Pinometostat(EPZ5676)、(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)

产品性质

CAS编号：1380288-87-8

分子式：C30H42N8O3

分子量：562.71

PubChem编号：57345410

英文别名：pinometostat|1380288-87-8|EPZ-5676|EPZ5676|Pinometostat, trans-|Pinometostat [INN]|Pinometostat anhydrous|Pinometostat(EPZ5676)|(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)

规格或纯度：≥98%

英文名称：Pinometostat (EPZ5676)

生化机理：The compound has a Ki value of 80 pM, and demonstrates 37,000-fold selectivity over all other methyltransferases tested. In cellular studies, EPZ-5676inhibited H3K79 methylation and MLL-fusion target gene expression and demonstrated potent cell killing that was selective for acute leukemia lines bearing MLL translocations.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：EPZ-5676是氨基核苷类DOT1L组蛋白甲基转移酶抑制剂，Ki为80 pM，比对其它多种PMTs的抑制性高37000倍。Pinometostat (EPZ5676) is an S-adenosyl methionine (SAM) competitive inhibitor of protein methyltransferase DOT1L with Ki of 80 pM in a cell-free assay, demonstrating >37,000-fold selectivity against all other PMTs tested, inhibits H3K79 methylation in tumor.

PubChem SID：488201822

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488201822

IUPAC Name：(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-[[[3-[2-(6-tert-butyl-1H-benzimidazol-2-yl)ethyl]cyclobutyl]-propan-2-ylamino]methyl]oxolane-3,4-diol

INCHI：InChI=1S/C30H42N8O3/c1-16(2)37(13-22-25(39)26(40)29(41-22)38-15-34-24-27(31)32-14-33-28(24)38)19-10-17(11-19)6-9-23-35-20-8-7-18(30(3,4)5)12-21(20)36-23/h7-8,12,14-17,19,22,25-26,29,39-40H,6,9-11,13H2,1-5H3,(H,35,36)(H2,31,32,33)/t17?,19?,22-,25-,26-,29-/m1/s1

InChi Key：LXFOLMYKSYSZQS-XKHGBIBOSA-N

Canonical SMILES：CC(C)N(CC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O)C4CC(C4)CCC5=NC6=C(N5)C=C(C=C6)C(C)(C)C

Isomeric SMILES：CC(C)N(C[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)N)O)O)C4CC(C4)CCC5=NC6=C(N5)C=C(C=C6)C(C)(C)C

PubChem CID：57345410

CAS Registry No.：1380288-87-8

ChEMBL Ligand：CHEMBL3087499

RCSB PDB Ligand：EP6

溶解性：≥28.15 mg/mL in DMSO; insoluble in H2O; ≥50.3 mg/mL in EtOH with ultrasonic

产品包装