产品名称

英文名称：TUG-770

同义词

TUG-770、1402601-82-4、3-(4-((2-(cyanomethyl)phenyl)ethynyl)-2-fluorophenyl)propanoic acid、3-[4-[2-[2-(cyanomethyl)phenyl]ethynyl]-2-fluorophenyl]propanoic acid、CHEMBL2386353、TUG770、3-(4-{[2-(Cyanomethyl)phenyl]ethynyl}-2-fluorophenyl)propanoic acid、3-(4-{2

产品性质

CAS编号：1402601-82-4

分子式：C19H14FNO2

分子量：307.32

PubChem编号：66553168

英文别名：TUG-770|1402601-82-4|3-(4-((2-(cyanomethyl)phenyl)ethynyl)-2-fluorophenyl)propanoic acid|3-[4-[2-[2-(cyanomethyl)phenyl]ethynyl]-2-fluorophenyl]propanoic acid|CHEMBL2386353|TUG770|3-(4-{[2-(Cyanomethyl)phenyl]ethynyl}-2-fluorophenyl)propanoic acid|3-(4-{2

规格或纯度：98%

英文名称：TUG-770

生化机理：DescriptionIC50 Value 6nM (hFFA1) [1]Tμg-770 is a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist for treatment of type 2 diabetes.in vitro Tμg-770 (Compound 22) displayed excellent physicochemical and in vitro ADME properties, with good aqueous solubility, good chemical stability, low lipophilicity, and decreased plasma protein binding (PPB). Tμg-770 furthermore showed excellent stability toward human liver microsomes (HLM), no inhibition of selected CYP-enzymes implicated in drμg-drμg interactions, no P-glycoprotein (P-gp) inhibition, and good permeability in the Caco-2 cell assay [1].in vivo Examination of Tμg-770 in an acute intraperitoneal glucose tolerance test (IPGTT) in normal mice revealed a good dose dependent response with maximal reduction in glucose level reached at 50 mg/kg. The effect of Tμg-770 was fully sustained after 29 days of daily oral treatment. Additional evaluation of Tμg-770 in rats confirmed a significant glucose lowering effect for the high doses already after 10 min and for all doses after 30 min [1].Clinical trial N/A

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：TUG-770 是一种有效的，选择性的， GPR40/FFA1 激动剂，对人 FFA1 的 EC50 为 6 nM。TUG-770 对 FFA1 的选择性高于 FFA2，FFA3，FFA4，PPARγ，其他受体，转运蛋白和酶。TUG-770 可用于 2 型糖尿病研究。TUG-770 is a potent, selective and orally active GPR40/FFA1 agonist with an EC50 of 6 nM for human FFA1. TUG-770 shows a high selectivity for FFA1 over FFA2, FFA3, FFA4, PPARγ, other receptors, transporters, and enzymes. TUG-770 can be uesd for type 2 diabetes research. TUG-770 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IUPAC Name：3-[4-[2-[2-(cyanomethyl)phenyl]ethynyl]-2-fluorophenyl]propanoic acid

INCHI：InChI=1S/C19H14FNO2/c20-18-13-14(6-8-17(18)9-10-19(22)23)5-7-15-3-1-2-4-16(15)11-12-21/h1-4,6,8,13H,9-11H2,(H,22,23)

InChi Key：KIZUBVPJNPVIIN-UHFFFAOYSA-N

Canonical SMILES：C1=CC=C(C(=C1)CC#N)C#CC2=CC(=C(C=C2)CCC(=O)O)F

Isomeric SMILES：C1=CC=C(C(=C1)CC#N)C#CC2=CC(=C(C=C2)CCC(=O)O)F

PubChem CID：66553168

ChEMBL Ligand：CHEMBL2386353

CAS Registry No.：1402601-82-4

GPCRdb Ligand：TUG-770

溶解性：25°C DMSO

产品包装