产品名称

英文名称：Dansylcadaverine

同义词

Dansylcadaverine、10121-91-2、monodansylcadaverine、Monodansyl cadaverine、n-(5-aminopentyl)-5-(dimethylamino)naphthalene-1-sulfonamide、1-Naphthalenesulfonamide, N-(5-aminopentyl)-5-(dimethylamino)-、N-(5-Aminopentyl)-5-(dimethylamino)naphthalene-1-sulphonamid、丹酰尸胺、N-(二甲基氨基萘磺酰)-1,5-戊二胺、N-(5-氨基戊基)-5-二甲基氨基萘-1-磺酰胺

产品性质

CAS编号：10121-91-2

分子式：C17H25N3O2S

分子量：335.46

Beilstein号：2951070

EC号：233-326-9

MDL号：MFCD00042704

PubChem编号：4247

别名：丹酰尸胺|N-(二甲基氨基萘磺酰)-1,5-戊二胺|N-(5-氨基戊基)-5-二甲基氨基萘-1-磺酰胺

英文别名：Dansylcadaverine|10121-91-2|monodansylcadaverine|Monodansyl cadaverine|n-(5-aminopentyl)-5-(dimethylamino)naphthalene-1-sulfonamide|1-Naphthalenesulfonamide, N-(5-aminopentyl)-5-(dimethylamino)-|N-(5-Aminopentyl)-5-(dimethylamino)naphthalene-1-sulphonamid

规格或纯度：≥97%

英文名称：Dansylcadaverine

生化机理：自发荧光染料丹酰尸胺或单丹磺酰尸胺（MDC）通常用于监测自噬。 由于离子捕获和与膜脂质的特异性相互作用的组合，单丹磺酰尸胺优先在自噬泡中积累。

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

产品介绍：Dansylcadaverine is a fluorescent amine probe, which is believed to directly inhibit vesicular transport. Studies indicate that Dansylcadaverine can act as a marker used to study autophagy in the cytoplasm and vacuoles of plants and mammalian cells. Dansylcadaverine functions by marking the autophagosomes, which allows researchers to follow the molecular components of the process throμghout. It is known that the specificity of Dansylcadaverine towards mammalian autophagosomes is due to ion trapping throμgh the acidic compartments of autophagosomes. In addition, Dansylcadaverine has biological applications in measuring cardiac autophagic flux, studying Parkinson's disease, peritoneal ovarian tumor dissemination, and respiratory diseases. This fluorescent tag is preferred over other due to its specificity and simplicity in detecting autophagic vesicles, which requires a brief exposure to the compound compared to previous methods.A fluorescent amine probe.Dansylcadaverine in methanol has a reported λex of 335 nm and λem of 512 nm. It has been used · as an endocytosis inhibitor in human proximal tubular HK-2 cells, mouse J774A.1 macrophages and human A549 epithelial cells · to label autophagic vacuoles in cardiomyocytes for fluorescence microscopy studies · in monodansylcadaverine (MDC) staining of fibroblasts in Ankylosing spondylitis (AS) samples.Dansylcadaverine is a fluorescent amine probe, which is believed to directly inhibit vesicular transport. Studies indicate that Dansylcadaverine can act as a marker used to study autophagy in the cytoplasm and vacuoles of plants and mammalian cells. Dansylcadaverine functions by marking the autophagosomes, which allows researchers to follow the molecular components of the process throughout. It is known that the specificity of Dansylcadaverine towards mammalian autophagosomes is due to ion trapping through the acidic compartments of autophagosomes. In addition, Dansylcadaverine has biological applications in measuring cardiac autophagic flux, studying Parkinson's disease, peritoneal ovarian tumor dissemination, and respiratory diseases. This fluorescent tag is preferred over other due to its specificity and simplicity in detecting autophagic vesicles, which requires a brief exposure to the compound compared to previous methods.A fluorescent amine probe

IUPAC Name：N-(5-aminopentyl)-5-(dimethylamino)naphthalene-1-sulfonamide

INCHI：InChI=1S/C17H25N3O2S/c1-20(2)16-10-6-9-15-14(16)8-7-11-17(15)23(21,22)19-13-5-3-4-12-18/h6-11,19H,3-5,12-13,18H2,1-2H3

InChi Key：MLEBFEHOJICQQS-UHFFFAOYSA-N

Canonical SMILES：CN(C)C1=CC=CC2=C1C=CC=C2S(=O)(=O)NCCCCCN

Isomeric SMILES：CN(C)C1=CC=CC2=C1C=CC=C2S(=O)(=O)NCCCCCN

WGK Germany：3

PubChem CID：4247

溶解性：10 mg/mL Methanol

敏感性：对空气敏感

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

产品包装