产品名称

英文名称：VS-5584 (SB2343)

同义词

1246560-33-7、VS-5584、5-(9-Isopropyl-8-methyl-2-morpholino-9H-purin-6-yl)pyrimidin-2-amine、VS-5584 (SB2343)、SB2343、SB-2343、5-(8-methyl-2-morpholin-4-yl-9-propan-2-ylpurin-6-yl)pyrimidin-2-amine、CHEMBL3393066、W71J4X250V、VS5584、2-Pyrimidinamine, 5-[8-methyl-

产品性质

CAS编号：1246560-33-7

分子式：C17H22N8O

分子量：354.41

PubChem编号：46912230

英文别名：1246560-33-7|VS-5584|5-(9-Isopropyl-8-methyl-2-morpholino-9H-purin-6-yl)pyrimidin-2-amine|VS-5584 (SB2343)|SB2343|SB-2343|5-(8-methyl-2-morpholin-4-yl-9-propan-2-ylpurin-6-yl)pyrimidin-2-amine|CHEMBL3393066|W71J4X250V|VS5584|2-Pyrimidinamine, 5-[8-methyl-

规格或纯度：≥98%

英文名称：VS-5584 (SB2343)

生化机理：VS-5584 (formerly SB-2343), is a novel, low-molecular weight compound with equivalent potent activity against mTOR (IC(50) = 37 nmol/L) and all class I phosphoinositide 3-kinase (PI3K) isoforms IC(50) PI3Kα = 16 nmol/L; PI3Kβ = 68 nmol/L; PI3Kγ = 25 nmol/L; PI3Kδ = 42 nmol/L, without relevant activity on 400 lipid and protein kinases. VS-5584 shows robust modulation of cellular PI3K/mTOR pathways, inhibiting phosphorylation of substrates downstream of PI3K and mTORC1/2. Antitumor agent.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：VS-5584 (SB2343)是PI3K/mTOR双重抑制剂，对mTOR和PI3Kα/β/δ/γ的IC50分别为3.4 nM和2.6-21 nM。VS-5584 (SB2343) is a potent and selective dual PI3K/mTOR inhibitor for mTOR, PI3Kα/β/δ/γ with IC50 of 3.4 nM and 2.6-21 nM, respectively.

IUPAC Name：5-(8-methyl-2-morpholin-4-yl-9-propan-2-ylpurin-6-yl)pyrimidin-2-amine

INCHI：InChI=1S/C17H22N8O/c1-10(2)25-11(3)21-14-13(12-8-19-16(18)20-9-12)22-17(23-15(14)25)24-4-6-26-7-5-24/h8-10H,4-7H2,1-3H3,(H2,18,19,20)

InChi Key：QYBGBLQCOOISAR-UHFFFAOYSA-N

Canonical SMILES：CC1=NC2=C(N=C(N=C2N1C(C)C)N3CCOCC3)C4=CN=C(N=C4)N

Isomeric SMILES：CC1=NC2=C(N=C(N=C2N1C(C)C)N3CCOCC3)C4=CN=C(N=C4)N

PubChem CID：46912230

CAS Registry No.：1246560-33-7

溶解性：DMSO 71 mg/mL Water <1 mg/mL Ethanol 3 mg/mL

产品包装