产品名称

英文名称：Oligomycin A from Streptomyces diastatochromogenes

同义词

MCH 32、Oligomycin A;MCH 32

产品性质

CAS编号：579-13-5

分子式：C45H74O11

分子量：791.06

Beilstein号：5702132

EC号：209-437-3

MDL号：MFCD00065705

PubChem编号：5281899

别名：Oligomycin A;MCH 32

英文别名：MCH 32

规格或纯度：≥97%

英文名称：Oligomycin A from Streptomyces diastatochromogenes

生化机理：Oligomycin inhibits membrane bound mitochondrial ATP synthase (ATPase), proton channel (pump, FO subunit) blockers thereby inhibiting oxidative phosphorylation and the electron transport chain.Macrolide antibiotic. ATP synthase inhibitor. Blocks the proton channel (Fo subunit) to uncouple oxidative phosphorylation. Shows antitumor activity. Active in vivo .

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Oligomycin A inhibits ATP5 (mitochondrial ATPases, F1F0) bound to the cell membrane. This compound stimulates lysosome acidification due to shunting of membrane potential at a concentration of 1.5-3 μM. The compound has been observed to Induce apoptosis in a variety of cell types along with inducing a switch from the apoptotic to necrotic pathway. It also exhibits broad nematocidal, antifungal, and antitumor activities. Oligomycin A has caused dissipated mitochondrial membrane potential, decreased cytoplasmic ATP contents and disassembled metaphase II oocyte spindles when introduced to mouse oocytes.Oligomycin is used to inhibit membrane bount mitochondrial ATP synthase. It is used to inhibit sucrose synthesis and 14C translocation in sunflower leaves, to study antibiotic resistance, and to study carotid chemoreceptor responses to O2 and CO2 in the cat.Oligomycin A inhibits ATP5 (mitochondrial ATPases, F1F0) bound to the cell membrane. This compound stimulates lysosome acidification due to shunting of membrane potential at a concentration of 1.5-3 μM. The compound has been observed to Induce apoptosis in a variety of cell types along with inducing a switch from the apoptotic to necrotic pathway. It also exhibits broad nematocidal, antifungal, and antitumor activities. Oligomycin A has caused dissipated mitochondrial membrane potential, decreased cytoplasmic ATP contents and disassembled metaphase II oocyte spindles when introduced to mouse oocytes.Oligomycin is used to inhibit membrane bount mitochondrial ATP synthase. It is used to inhibit sucrose synthesis and 14C translocation in sunflower leaves, to study antibiotic resistance, and to study carotid chemoreceptor responses to O2 and CO2 in the cat.

IUPAC Name：(1S,4E,5'R,6R,6'R,7S,8R,10S,11S,12R,14S,15R,16S,18E,20E,22S,25R,27S,28R,29S)-22-ethyl-7,11,14,15-tetrahydroxy-6'-[(2S)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethylspiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-oxane]-3,9,13-trione

INCHI：InChI=1S/C45H74O11/c1-12-34-17-15-13-14-16-27(4)42(51)44(11,53)43(52)32(9)40(50)31(8)39(49)30(7)38(48)26(3)18-21-37(47)54-41-29(6)35(20-19-34)55-45(33(41)10)23-22-25(2)36(56-45)24-28(5)46/h13-15,17-18,21,25-36,38,40-42,46,48,50-51,53H,12,16,19-20,22-24H2,1-11H3/b14-13+,17-15+,21-18+/t25-,26-,27+,28+,29+,30-,31-,32-,33-,34-,35-,36-,38+,40+,41+,42-,44+,45-/m1/s1

InChi Key：MNULEGDCPYONBU-WMBHJXFZSA-N

Canonical SMILES：CCC1CCC2C(C(C(C3(O2)CCC(C(O3)CC(C)O)C)C)OC(=O)C=CC(C(C(C(=O)C(C(C(C(=O)C(C(C(CC=CC=C1)C)O)(C)O)C)O)C)C)O)C)C

Isomeric SMILES：CC[C@H]\1CC[C@@H]2[C@@H]([C@@H]([C@H]([C@@]3(O2)CC[C@H]([C@H](O3)C[C@H](C)O)C)C)OC(=O)/C=C/[C@H]([C@@H]([C@H](C(=O)[C@H]([C@@H]([C@H](C(=O)[C@@]([C@@H]([C@H](C/C=C/C=C1)C)O)(C)O)C)O)C)C)O)C)C

WGK Germany：3

RTECS：RK3328000

PubChem CID：5281899

溶解性：Soluble in DMSO (300 mg/ml), ethanol (200 mg/ml), acetone (800 mg/ml), glacial acetic acid (37.5 g/100ml) at 25 °C, water (2 mg/100ml) at 25 °C, ether (28 g/100ml) at 25 °C, and benzene (6 g/100ml) at 25 °C.

密度：1.14

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowedH302 Harmful if swallowedH370 Causes damage to organs

预防措施声明：P321,P405,P501,P264,P260,P270,P330,P301+P316,P301+P317,P308+P316

个人防护装备：dust mask type N95 (US),Eyeshields,Gloves

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