产品名称

英文名称：6-Nitroveratraldehyde

同义词

6-Nitroveratraldehyde、20357-25-9、4,5-Dimethoxy-2-nitrobenzaldehyde、DMNB、Benzaldehyde, 4,5-dimethoxy-2-nitro-、3,4-Dimethoxy-6-nitrobenzaldehyde、4,5-dimethoxy-2-nitro-benzaldehyde、MFCD00007134、3V2SVJ99E2、CHEMBL1332518、NSC-65590、6-Nitro veratraldehyde、2-Nitr、3,4-二甲氧基-6-硝基苯甲醛

产品性质

CAS编号：20357-25-9

分子式：O2NC6H2-3,4-(OCH3)2CHO

分子量：211.17

Beilstein号：8262

EC号：243-762-1

MDL号：MFCD00007134

PubChem编号：88505

别名：3,4-二甲氧基-6-硝基苯甲醛

英文别名：6-Nitroveratraldehyde|20357-25-9|4,5-Dimethoxy-2-nitrobenzaldehyde|DMNB|Benzaldehyde, 4,5-dimethoxy-2-nitro-|3,4-Dimethoxy-6-nitrobenzaldehyde|4,5-dimethoxy-2-nitro-benzaldehyde|MFCD00007134|3V2SVJ99E2|CHEMBL1332518|NSC-65590|6-Nitro veratraldehyde|2-Nitr

规格或纯度：≥85.0%(GC)

英文名称：6-Nitroveratraldehyde

储存温度：充氩

运输条件：常规运输

产品介绍：DMNB (4,5-dimethoxy-2-nitrobenzaldehyde) is a cell-permeable vanillin derivative and potent inhibitor of DNA-PK (IC50 = 15 μM). DMNB is shown in experiments to increase DR4/DR5 mRNA levels and their surface expression and decrease c-FLIP mRNA levels in K56. DMNB is also an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair.6-Nitroveratraldehyde has been used in the preparation of · no-carrier-added 6-18F-fluoro-L-dopa, fundamental tracer for cerebral positron emission tomography studies of dopaminergic system in humans · o-nitroaryl-bis(5-methylfur-2-yl)methanes, versatile synthons for the synthesis of nitrogen-containing heterocyclesDMNB (4,5-dimethoxy-2-nitrobenzaldehyde) is a cell-permeable vanillin derivative and potent inhibitor of DNA-PK (IC50 = 15 μM). DMNB is shown in experiments to increase DR4/DR5 mRNA levels and their surface expression and decrease c-FLIP mRNA levels in K56. DMNB is also an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair.

IUPAC Name：4,5-dimethoxy-2-nitrobenzaldehyde

INCHI：InChI=1S/C9H9NO5/c1-14-8-3-6(5-11)7(10(12)13)4-9(8)15-2/h3-5H,1-2H3

InChi Key：YWSPWKXREVSQCA-UHFFFAOYSA-N

Canonical SMILES：COC1=C(C=C(C(=C1)C=O)[N+](=O)[O-])OC

Isomeric SMILES：COC1=C(C=C(C(=C1)C=O)[N+](=O)[O-])OC

PubChem CID：88505

Reaxy-Rn：395599

溶解性：Insoluble in water. Soluble to 25 mM in ethanol with gentle warming and to 100 mM in DMSO.

敏感性：对光线、空气敏感

熔点：132 °C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH302 Harmful if swallowed

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P264+P265,P301+P317,P337+P317,P332+P317,P319

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