产品名称

英文名称：Grubbs Catalyst, 2nd Generation

同义词

246047-72-3、Grubbs Catalyst 2nd Generation、(1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium、Grubbs Catalyst, 2nd Generation、benzylidene-[1,3-bis(2,4,6-trimethylphenyl)imidazolidin-2-ylidene]-、Umicore Grubbs Catalyst M204、格拉布催化剂、Grubbs催化剂

产品性质

CAS编号：246047-72-3

分子式：C46H65Cl2N2PRu

分子量：848.97

MDL号：MFCD03453237

PubChem编号：11147261

别名：Umicore Grubbs Catalyst M204|格拉布催化剂|Grubbs催化剂

英文别名：246047-72-3|Grubbs Catalyst 2nd Generation|(1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium|Grubbs Catalyst, 2nd Generation|benzylidene-[1,3-bis(2,4,6-trimethylphenyl)imidazolidin-2-ylidene]-

规格或纯度：97%

英文名称：Grubbs Catalyst, 2nd Generation

储存温度：2-8°C储存,充氩

运输条件：冰袋运输

产品介绍：Grubbs第二代催化剂 和第一代催化剂相比更有活性，且具有更广泛的底物范围，包括对空间有要求或失活的烯烃，如1,1 - 二取代烯烃和α，β-不饱和羰基化合物ApplicationGrubbs Catalyst® M204 can be used as a catalyst for ring-closing metathesis (RCM), cross-metathesis, and ring-opening metathesis polymerization (ROMP). It is also used to synthesize trisubstituted olefins with excellent functional group tolerance and selectivity via cross-metathesis and ring closing metathesis reactions.It can also be used as a catalyst• To synthesize coumarins from phenolic compounds via RCM.• To cleave secondary (E)-allyl vic-diols to aldehydes.Grubbs 2nd Generation Catalyst Generally more active compared to 1st generation catalysts and with a broader substrate scope, including sterically demanding or deactivated olefins such as 1,1-disubstituted olefins and α,β-unsaturated carbonylsApplicationGrubbs Catalyst® M204 can be used as a catalyst for ring-closing metathesis (RCM), cross-metathesis, and ring-opening metathesis polymerization (ROMP). It is also used to synthesize trisubstituted olefins with excellent functional group tolerance and selectivity via cross-metathesis and ring closing metathesis reactions.It can also be used as a catalyst• To synthesize coumarins from phenolic compounds via RCM.• To cleave secondary (E)-allyl vic-diols to aldehydes.Product classM-P, Homogeneous Catalysts, N-Heterocyclic Carbene Ligands, M-C, Grubbs Catalyst® 2nd Generation, Carbene Ligands, SIMes, Phosphorus Ligands - AchiralReaction typeAlkene Metathesis, Acyclic Diene Metathesis, Cross Metathesis, Ring Arrangement Metathesis , Ring Closing Metathesis, Ring Opening Metathesis, Ring Opening Metathesis Polymerization, Self MetathesisChemical propertiesChemical formulaC46H65Cl2N2PRuEmpirical formula(SIMes)Ru(PCy3)(benzylidene)Cl2Molecular weight848.97MetalRuTheoretical metal content12Physical statepowderColororange-brownApplications & referencesAsymmetric synthesis of new cyclic fluorinated amino-acidsReference European Journal of Organic Chemistry, March 2018Photoinduced strain-assisted synthesis of a stiff-stilbene polymer by ring-opening metathesis polymerization.Reference Chem. Eur. J. 2020 (10.1002/chem.20200418)Facile synthetic route to [3.n]thiacyclophanes via ring-closing metathesis.Reference Eur. J. Org. Chem. 2020 (10.1002/ejoc.202000697)RCM-Based Total Synthesis of the Antibiotic Disciformycin B.Reference Angew. Chem. Int. Ed. 2020 (doi.org/10.1002/anie.202004589)Sequential two-fold Claisen Rearrangement, One-pot Ring Closing Metathesis and Cross-metathesis as a Route to Substituted Benzo[b]azepine-2-one, Benzo[b]azepine and Benzo[b]oxepine Derivatives.Reference Helv Chem Acta 2020 ASAP (doi.org/10.1002/hlca.202000216)Sequence-regulated vinyl polymers via iterative atom transfer radical additions and acyclic diene metathesis polymerization.Reference Polym Chem 2020 ASAP (doi.org/10.1039/D0PY01564D)

IUPAC Name：benzylidene-[1,3-bis(2,4,6-trimethylphenyl)imidazolidin-2-ylidene]-dichlororuthenium;tricyclohexylphosphane

INCHI：InChI=1S/C21H26N2.C18H33P.C7H6.2ClH.Ru/c1-14-9-16(3)20(17(4)10-14)22-7-8-23(13-22)21-18(5)11-15(2)12-19(21)6;1-4-10-16(11-5-1)19(17-12-6-2-7-13-17)18-14-8-3-9-15-18;1-7-5-3-2-4-6-7;;;/h9-12H,7-8H2,1-6H3;16-18H,1-15H2;1-6H;2*1H;/q;;;;;+2/p-2

InChi Key：FCDPQMAOJARMTG-UHFFFAOYSA-L

Canonical SMILES：CC1=CC(=C(C(=C1)C)N2CCN(C2=[Ru](=CC3=CC=CC=C3)(Cl)Cl)C4=C(C=C(C=C4C)C)C)C.C1CCC(CC1)P(C2CCCCC2)C3CCCCC3

Isomeric SMILES：CC1=CC(=C(C(=C1)C)N2CCN(C2=[Ru](=CC3=CC=CC=C3)(Cl)Cl)C4=C(C=C(C=C4C)C)C)C.C1CCC(CC1)P(C2CCCCC2)C3CCCCC3

WGK Germany：3

PubChem CID：11147261

UN Number：1325

溶解性：Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Very Slightly, Heated

敏感性：对空气和光线敏感

熔点：143.5-148.5°C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH228 Flammable solid

预防措施声明：P261,P305+P351+P338,P280,P370+P378,P210,P302+P352,P321,P405,P501,P240,P264,P271,P241,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

个人防护装备：Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

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