产品名称

英文名称：BML-190

同义词

2854-32-2、BML-190、2-(1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-1-morpholinoethanone、Indomethacin morpholinylamide、BML 190、IMMA、CHEMBL72631、Ethanone, 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(4-morpholinyl)-、2-(1-(4-chlorobenz、吲哚美辛吗啉代酰胺

产品性质

CAS编号：2854-32-2

分子式：C23H23ClN2O4

分子量：426.89

PubChem编号：2415

别名：吲哚美辛吗啉代酰胺

英文别名：2854-32-2|BML-190|2-(1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-1-morpholinoethanone|Indomethacin morpholinylamide|BML 190|IMMA|CHEMBL72631|Ethanone, 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(4-morpholinyl)-|2-(1-(4-chlorobenz

规格或纯度：98%

英文名称：BML-190

生化机理：BML-190 is a potent and selective CB2 receptor ligand (Ki values are 435 nM and > 2 μM for CB2 and CB1 respectively). Studies involving HEK-293 cells indicate that BML-190 increases the accumulation of cAMP, via forskolin-stimulated mechanism. Alternate studies sμggest that BML-190 reduces the toxicity of culture supernatants to SH-SY5Y human neutroblastoma cells. Various research sμggests that BML-190 is an essential tool in studying the proliferation of neuroblastoma.Selective CB 2 receptor inverse agonist (K i = 435 nM). Reduces LPS-induced NO and IL-6 production. Inhibits LPS-induced PGE2 production and COX-2 induction.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

PubChem SID：488179703

IUPAC Name：2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-1-morpholin-4-ylethanone

INCHI：InChI=1S/C23H23ClN2O4/c1-15-19(14-22(27)25-9-11-30-12-10-25)20-13-18(29-2)7-8-21(20)26(15)23(28)16-3-5-17(24)6-4-16/h3-8,13H,9-12,14H2,1-2H3

InChi Key：BJSDNVVWJYDOLK-UHFFFAOYSA-N

Canonical SMILES：CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)N4CCOCC4

Isomeric SMILES：CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)N4CCOCC4

PubChem CID：2415

溶解性：DMSO 22 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

产品包装