产品名称

英文名称：URB597

同义词

546141-08-6、URB597、URB-597、3'-Carbamoyl-[1,1'-biphenyl]-3-yl cyclohexylcarbamate、URB 597、KDS-4103、FAAH Inhibitor II、[3-(3-carbamoylphenyl)phenyl] N-cyclohexylcarbamate、C20H22N2O3、Org-231295、3-(3-carbamoylphenyl)phenyl N-cyclohexylcarbamate、PX47LB88FO、CHEM

产品性质

CAS编号：546141-08-6

分子式：C20H22N2O3

分子量：338.4

MDL号：MFCD05863934

PubChem编号：1383884

英文别名：546141-08-6|URB597|URB-597|3'-Carbamoyl-[1,1'-biphenyl]-3-yl cyclohexylcarbamate|URB 597|KDS-4103|FAAH Inhibitor II|[3-(3-carbamoylphenyl)phenyl] N-cyclohexylcarbamate|C20H22N2O3|Org-231295|3-(3-carbamoylphenyl)phenyl N-cyclohexylcarbamate|PX47LB88FO|CHEM

规格或纯度：≥98%

英文名称：URB597

生化机理：FAAH Inhibitor II is a cell-permeable carbamate compound that acts as a potent, selective, and irreversible inhibitor of FAAH (fatty acid amide hydrolase; IC50 = 4.6 nM in brain membranes). Shown to block anandamide breakdown in rat cortical neurons (IC50 = 500 pM) and modulate anxiety in rats (ID50 = 0.15 mg/Kg). Does not affect the activities of several serine hydrolases (IC50 > 30 μM), including AChE (acetylcholinesterase), BCh (butyrylcholinesterase) and MGL (monoglyceride lipase). FAAH Inhibitor II does not interfere with the binding of anandamide to cannabinoid receptors CB1 and CB2 (IC50 > 100 μM), as well as several ion-channels and neurotransmitter transporters.Potent and selective fatty acid amide hydrolase (FAAH) inhibitor (IC 50 values are 4.6 nM in brain membranes and 0.5 nM in neurons). Causes accumulation of anandamide. Displays anxiolytic, antidepressant, antinociceptive and analgesic effect.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：URB597是一种口服生物有效的FAAH抑制剂，IC50为4.6 nM，对其他大麻黄素相关靶点没有抑制活性。Phase 1。A cell permeable carbamate and potent inhibitor of fatty acid amide hydrolase (FAHH)URB597 is a potent, orally bioavailable FAAH inhibitor with IC50 of 4.6 nM, with no activity on other cannabinoid-related targets. Phase 1.A cell permeable carbamate and potent inhibitor of fatty acid amide hydrolase (FAHH)

IUPAC Name：[3-(3-carbamoylphenyl)phenyl] N-cyclohexylcarbamate

INCHI：InChI=1S/C20H22N2O3/c21-19(23)16-8-4-6-14(12-16)15-7-5-11-18(13-15)25-20(24)22-17-9-2-1-3-10-17/h4-8,11-13,17H,1-3,9-10H2,(H2,21,23)(H,22,24)

InChi Key：ROFVXGGUISEHAM-UHFFFAOYSA-N

Canonical SMILES：C1CCC(CC1)NC(=O)OC2=CC=CC(=C2)C3=CC(=CC=C3)C(=O)N

Isomeric SMILES：C1CCC(CC1)NC(=O)OC2=CC=CC(=C2)C3=CC(=CC=C3)C(=O)N

WGK Germany：3

PubChem CID：1383884

Wikipedia：URB597

CAS Registry No.：546141-08-6

ChEMBL Ligand：CHEMBL184238

溶解性：Soluble in DMSO (~14 mg/ml), DMF (~10 mg/ml), 11 DMFPBS(pH 7.2) (500 ug/ml), 12 DMSOPBS(pH 7.2) (500 ug/ml), water (500 ug/ml) at 25 °C, and ethanol (5 mg/ml).

象形图：

信号词：Warning

危险声明：H319 Causes serious eye irritationH400 Very toxic to aquatic lifeH410 Very toxic to aquatic life with long lasting effects

预防措施声明：P305+P351+P338,P273,P280,P501,P391,P264+P265,P337+P317

个人防护装备：Eyeshields, Gloves

产品包装