产品名称

英文名称：Eliprodil

同义词

Eliprodil、119431-25-3、Eliprodil [INN]、C20H23ClFNO、SL-820715、alpha-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol、1-(4-chlorophenyl)-2-[4-[(4-fluorophenyl)methyl]piperidin-1-yl]ethanol、CHEMBL28564、YW62A6TW29、DTXSID1045744、1-Piperidineethan

产品性质

CAS编号：119431-25-3

分子式：C20H23ClFNO

分子量：347.85

MDL号：MFCD00866651

PubChem编号：60703

英文别名：Eliprodil|119431-25-3|Eliprodil [INN]|C20H23ClFNO|SL-820715|alpha-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol|1-(4-chlorophenyl)-2-[4-[(4-fluorophenyl)methyl]piperidin-1-yl]ethanol|CHEMBL28564|YW62A6TW29|DTXSID1045744|1-Piperidineethan

规格或纯度：≥98% (HPLC)

英文名称：Eliprodil

生化机理：在多胺调节位点起作用的非竞争性NMDA受体拮抗剂。对含GluN2A（NR2A）和GluN2C（NR2C）的受体具有选择性（对于IC50值分别为1，> 100和>100μM）。也是σ1配体（Ki =0.013μM）。拮抗神经元电压门控的Ca2 +通道，并选择性抑制延迟整流器K +电流（IKr）的快速分量。具有神经保护作用。有关最新命名约定，请参阅《 IUPHAR药理学指南》。

储存温度：2-8°C储存

运输条件：冰袋运输

备注：卖完停产，不再备货

产品介绍：Eliprodil is a non-competitive NMDA receptor antagonist which acts at the polyamine modulatory site. Eliprodil is selective for NMDA epsilon 2 (NR2B-containing receptors) over NR2A- and NR2C-containing receptors (IC50 values are 1, > 100 and > 100 μM respectively) in addition to acting as a Sigma Receptor (σ1 ligand) (Ki = 0.013 μM). Eliprodil antagonizes neuronal voltage-gated Ca2+ channels and selectively inhibits the rapid component of the delayed rectifier K+ current (IKr). Furthermore, Eliprodil is reported to act as a neuroprotective.Eliprodil is a non-competitive NMDA receptor antagonist which acts at the polyamine modulatory site. Eliprodil is selective for NMDA epsilon 2 (NR2B-containing receptors) over NR2A- and NR2C-containing receptors (IC50 values are 1, > 100 and > 100 μM respectively) in addition to acting as a Sigma Receptor (σ1 ligand) (Ki = 0.013 μM). Eliprodil antagonizes neuronal voltage-gated Ca2+ channels and selectively inhibits the rapid component of the delayed rectifier K+ current (IKr). Furthermore, Eliprodil is reported to act as a neuroprotective.

IUPAC Name：1-(4-chlorophenyl)-2-[4-[(4-fluorophenyl)methyl]piperidin-1-yl]ethanol

INCHI：InChI=1S/C20H23ClFNO/c21-18-5-3-17(4-6-18)20(24)14-23-11-9-16(10-12-23)13-15-1-7-19(22)8-2-15/h1-8,16,20,24H,9-14H2

InChi Key：GGUSQTSTQSHJAH-UHFFFAOYSA-N

Canonical SMILES：C1CN(CCC1CC2=CC=C(C=C2)F)CC(C3=CC=C(C=C3)Cl)O

Isomeric SMILES：C1CN(CCC1CC2=CC=C(C=C2)F)CC(C3=CC=C(C=C3)Cl)O

WGK Germany：3

PubChem CID：60703

溶解性：溶于DMSO, 最高浓度 (mg/mL) 8.7, 最高浓度(mM) 25

象形图：

信号词：Warning

危险声明：H319 Causes serious eye irritationH400 Very toxic to aquatic lifeH410 Very toxic to aquatic life with long lasting effects

预防措施声明：P305+P351+P338,P273,P280,P501,P391,P264+P265,P337+P317

个人防护装备：Eyeshields, Gloves

产品包装