产品名称

英文名称：Tolnaftate

同义词

NSC 233648、m,N-Dimethylthiocarbanilic acid O-2-naphthyl ester、Ting antifungal cream、Fungistop、Tinactin powder、Tolnaftate (USANUSPINNBANJAN)、Tolnaftate Oil、Tolnaftate serum、Fungus Relief、Naphthiomate-T、meijerantifungal、Naphthiomate T、NP-27 Cream、06KB62、托萘酯

产品性质

CAS编号：2398-96-1

分子式：C19H17NOS

分子量：307.41

EC号：219-266-6

MDL号：MFCD00056611

PubChem编号：5510

别名：托萘酯

英文别名：NSC 233648|m,N-Dimethylthiocarbanilic acid O-2-naphthyl ester|Ting antifungal cream|Fungistop|Tinactin powder|Tolnaftate (USANUSPINNBANJAN)|Tolnaftate Oil|Tolnaftate serum|Fungus Relief|Naphthiomate-T|meijerantifungal|Naphthiomate T|NP-27 Cream|06KB62

规格或纯度：≥98%

英文名称：Tolnaftate

生化机理：It prevents ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms. Tolnaftate inhibits biosynthesis of aflatoxin.

应用：It is used to study the mechanism of ergosterol (sterol) biosynthesis at the rate-limiting step of squalene epoxidase inhibition. Tolnaftate is clinically used to treat cutaneous infections such as athlete′s foot, jock itch, and ringworm. It also has been used as a comparator compound for antifungal efficiency studies.

储存温度：2-8°C储存

运输条件：冰袋运输

产品介绍：Tolnaftate 是一种合成的硫代氨基甲酸酯，用作抗真菌剂。It is used to study the mechanism of ergosterol (sterol) biosynthesis at the rate-limiting step of squalene epoxidase inhibition. Tolnaftate is clinically used to treat cutaneous infections such as athlete′s foot, jock itch, and ringworm. It also has been used as a comparator compound for antifungal efficiency studies.Tolnaftate is a synthetic thiocarbamate used as an anti-fungal agent.It is used to study the mechanism of ergosterol (sterol) biosynthesis at the rate-limiting step of squalene epoxidase inhibition. Tolnaftate is clinically used to treat cutaneous infections such as athlete′s foot, jock itch, and ringworm. It also has been used as a comparator compound for antifungal efficiency studies.

IUPAC Name：O-naphthalen-2-yl N-methyl-N-(3-methylphenyl)carbamothioate

INCHI：InChI=1S/C19H17NOS/c1-14-6-5-9-17(12-14)20(2)19(22)21-18-11-10-15-7-3-4-8-16(15)13-18/h3-13H,1-2H3

InChi Key：FUSNMLFNXJSCDI-UHFFFAOYSA-N

Canonical SMILES：CC1=CC(=CC=C1)N(C)C(=S)OC2=CC3=CC=CC=C3C=C2

Isomeric SMILES：CC1=CC(=CC=C1)N(C)C(=S)OC2=CC3=CC=CC=C3C=C2

PubChem CID：5510

溶解性：DMSO 62 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

敏感性：对热敏感

熔点：110-113°C

象形图：

信号词：Warning

危险声明：H319 Causes serious eye irritationH411 Toxic to aquatic life with long lasting effectsH400 Very toxic to aquatic lifeH410 Very toxic to aquatic life with long lasting effects

预防措施声明：P305+P351+P338,P273,P280,P501,P391,P264+P265,P337+P317

Merck Index：9519

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