产品名称

英文名称：Tyrphostin A1

同义词

Tyrphostin A1、Tyrphostin 1、2826-26-8、(4-Methoxybenzylidene)malononitrile、2-[(4-methoxyphenyl)methylidene]propanedinitrile、2-(4-Methoxybenzylidene)malononitrile、AG 9、Propanedinitrile,2-[(4-methoxyphenyl)methylene]-、Tyrphostin 1;AG9、((4-Methoxyphenyl)methyl、酪氨酸磷酸化抑制剂1、(4-甲氧基苯亚甲基)丙二睛

产品性质

CAS编号：2826-26-8

分子式：C11H8N2O

分子量：184.2

MDL号：MFCD00019787

PubChem编号：2063

别名：酪氨酸磷酸化抑制剂1|(4-甲氧基苯亚甲基)丙二睛

英文别名：Tyrphostin A1|Tyrphostin 1|2826-26-8|(4-Methoxybenzylidene)malononitrile|2-[(4-methoxyphenyl)methylidene]propanedinitrile|2-(4-Methoxybenzylidene)malononitrile|AG 9|Propanedinitrile,2-[(4-methoxyphenyl)methylene]-|Tyrphostin 1;AG9|((4-Methoxyphenyl)methyl

规格或纯度：98%

英文名称：Tyrphostin A1

生化机理：无效的tyrphostin。tyrphostin的阴性对照，例如AG 490。抑制CD40信号通路。减少巨噬细胞中IL-12的产生。阻止CD40L诱导的NFκB易位至细胞核。在体内显示抗过敏作用。

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：产品介绍Tyrphostin A1(AG9)能抑制巨噬细胞培养中CD40L刺激的IL-12产生和抗原诱导的Th1细胞生成。Product descriptionTyrphostin A1(AG9) inhibits CD40L-stimulatedIL-12production in macrophage cultures and antigen-induced generation of Th1 cells. IC50 value TargetIL-12production inhibitor Addition of increasing concentration of A1 resulted in a dose dependent decrease ofIL-12p40, with maximal inhibition (62.5%) occurring at a dose of 10 μM. tyrphostin A1 blocks CD40L-induced translocation ofNF-κBto the nucleus, and reduces the activation ofIL-12p40 gene. In vivo therapy with A1 leads to decrease in generation of myelin basic protein (MBP) specific encephalitogenic T cells. In addition, treatment of SJL/J mice with A1 results in attenuation of experimental allergic encephalomyelitis (EAE) . Tyrphostin A1 is a much weaker inhibitor of TK than other tyrphostins (IC50>1250 μM for epidermal growth factor receptor (EGFR) kinase), and therefore often used to differentiate TK-mediated effects of tyrphostins from other non-specific effects.ApplicationTyrphostin 1 has been used to study its effect on the increase of transgene expression in HeLa and NIH3T3 cells.

IUPAC Name：2-[(4-methoxyphenyl)methylidene]propanedinitrile

INCHI：InChI=1S/C11H8N2O/c1-14-11-4-2-9(3-5-11)6-10(7-12)8-13/h2-6H,1H3

InChi Key：UOHFCPXBKJPCAD-UHFFFAOYSA-N

Canonical SMILES：COC1=CC=C(C=C1)C=C(C#N)C#N

Isomeric SMILES：COC1=CC=C(C=C1)C=C(C#N)C#N

WGK Germany：3

PubChem CID：2063

CAS Registry No.：2826-26-8

ChEMBL Ligand：CHEMBL77456

敏感性：对热敏感

熔点：115 °C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH301 Toxic if swallowed

预防措施声明：P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P270,P362+P364,P330,P264+P265,P301+P316,P337+P317,P332+P317

个人防护装备：Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

产品包装