产品名称

英文名称：Gemcitabine

同义词

2'-Deoxy-2',2'-difluorocytidine 、 2',2'-Difluorodeoxycytidine、2'-脱氧-2',2'-二氟胞苷

产品性质

CAS编号：95058-81-4

分子式：C9H11F2N3O4

分子量：263.2

MDL号：MFCD00869720

PubChem编号：60750

别名：2'-脱氧-2',2'-二氟胞苷

英文别名：2'-Deoxy-2',2'-difluorocytidine | 2',2'-Difluorodeoxycytidine

规格或纯度：≥99%

英文名称：Gemcitabine

生化机理：Gemcitabine is a widely used antitumor agents in both clinics and research labs. It is an antineoplastic agent and antimetabolite. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. Gemcitabine inhibits proliferation BxPC-3 pancreatic cancer cell line with IC50 of 0.06 μM.Cytidine analog. Antimetabolite. Induces apoptosis. Blocks cytosine nucleotide conversion into the deoxy derivative and blocks incorporation of the thymidine nucleotide into the DNA strand. Shows antitumor effects in vivo.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：2'-Deoxy-2',2'-difluorocytidine is an irreversible inactivator of R1 and R2 (ribonucleoside diphosphate reductase, RDPR) from Escherichia coli.An irreversible inactivator of bacterial ribonucleoside diphosphate reductase.Soluble in ethanol (~0.25 mg/ml), DMSO (15 mg/ml at 25 °C), DMF (~0.1 mg/ml), water (<1 mg/ml at 25 °C), and PBS pH 7.2 (~2 mg/ml).2'-Deoxy-2',2'-difluorocytidine is an irreversible inactivator of R1 and R2 (ribonucleoside diphosphate reductase, RDPR) from Escherichia coli.Soluble in ethanol (~0.25 mg/ml), DMSO (15 mg/ml at 25 °C), DMF (~0.1 mg/ml), water (<1 mg/ml at 25 °C), and PBS pH 7.2 (~2 mg/ml).An irreversible inactivator of bacterial ribonucleoside diphosphate reductase.

IUPAC Name：4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

INCHI：InChI=1S/C9H11F2N3O4/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17)/t4-,6-,7-/m1/s1

InChi Key：SDUQYLNIPVEERB-QPPQHZFASA-N

Canonical SMILES：C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)(F)F

Isomeric SMILES：C1=CN(C(=O)N=C1N)[C@H]2C([C@@H]([C@H](O2)CO)O)(F)F

关联CAS：122111-03-9

PubChem CID：60750

DrugBank Ligand：DB00441

Wikipedia：Gemcitabine

ChEMBL Ligand：CHEMBL888

CAS Registry No.：95058-81-4

RCSB PDB Ligand：GEO

DrugCentral Ligand：1283

溶解性：DMSO 15 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

敏感性：对热敏感

比旋光度：74° (C=1,MeOH)

熔点：217-222°C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH312 Harmful in contact with skinH360 May damage fertility or the unborn childH340 May cause genetic defectsH361 Suspected of damaging fertility or the unborn child

预防措施声明：P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P281,P362+P364,P203,P264+P265,P318,P317,P337+P317,P332+P317

Merck Index：4386

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