产品名称

英文名称：(S)-10-Hydroxycamptothecin

同义词

4-Ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione、4-Ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (10-hydroxycamptothecin)、1H-Pyrano[3',7]indolizino[1,2-b]quinoline-3,14(4H,12H)、10-羟基喜树碱

产品性质

CAS编号：19685-09-7

分子式：C20H16N2O5

分子量：364.35

MDL号：MFCD02093100

PubChem编号：97226

别名：10-羟基喜树碱

英文别名：4-Ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione|4-Ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (10-hydroxycamptothecin)|1H-Pyrano[3',7]indolizino[1,2-b]quinoline-3,14(4H,12H)

规格或纯度：98%

英文名称：(S)-10-Hydroxycamptothecin

生化机理：10-Hydroxycamptothecin is a camptothecin derivative that inhibits DNA topoisomerase by enacting strand breaks in chromosomal DNA and inducing apoptosis.10-Hydroxycamptothecin is an inhibitor of Topo I.

应用：A camptothecin derivative that inhibits DNA topoisomerase I.

储存温度：2-8°C储存

运输条件：冰袋运输

产品介绍：A camptothecin derivative that inhibits DNA topoisomerase I.A camptothecin derivative that inhibits DNA topoisomerase I.

IUPAC Name：(19S)-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione

INCHI：InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1

InChi Key：HAWSQZCWOQZXHI-FQEVSTJZSA-N

Canonical SMILES：CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O

Isomeric SMILES：CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O

RTECS：UQ0491700

PubChem CID：97226

Reaxy-Rn：3019077

溶解性：Soluble in DMSO (5 mg/ml), DMF, and methanol

比旋光度：35.3° (C=0.11,CH2Cl2MeOH=41)

熔点：267°C(lit.)

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

产品包装