产品名称

英文名称：Irbesartan

同义词

BMS-186295、IRBESARTAN [VANDF]、Irbesartan- Bio-X、HY-B0202、Irbesartan [USANUSPINNBAN]、NSC758696、NSC-758696、BCPP000202、SR-47436、2-butyl-3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1,3-diazaspiro[4.4]non-1-en-4-one、HMS2232F23、Avapro (TN)、GTPL6908、HMS371、伊贝沙坦

产品性质

CAS编号：138402-11-6

分子式：C25H28N6O

分子量：428.53

EC号：604-078-2

MDL号：MFCD00864464

PubChem编号：3749

别名：伊贝沙坦

英文别名：BMS-186295|IRBESARTAN [VANDF]|Irbesartan- Bio-X|HY-B0202|Irbesartan [USANUSPINNBAN]|NSC758696|NSC-758696|BCPP000202|SR-47436|2-butyl-3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1,3-diazaspiro[4.4]non-1-en-4-one|HMS2232F23|Avapro (TN)|GTPL6908|HMS371

规格或纯度：≥98%

英文名称：Irbesartan

生化机理：Irbesartan is a highly potent and selective antagonist of the AT1 (angiotensin II type 1) receptor with an IC50 = 1.3 nM. This compound has no affinity for AT2 receptors. Pretreatment with irbesartan decreases angiotensin II-induced apoptosis in rat vascular smooth muscle cells by blocking angiotensin II internalization in a concentration-dependent manner.Selective, competitive AT 1 receptor antagonist. Reduces vasopressin and aldosterone secretion. Shows vasodilatory and antihypertensive effects in vivo. Orally active.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Irbesartan是一种高效的特定血管紧张素II 1型(AT1)受体拮抗剂，IC50为1.3 nM。An angiotensin II type 1 (AII1)-receptor antagonist.Product DescribtionIrbesartan (SR-47436, BMS-186295) is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM.An angiotensin II type 1 (AII1)-receptor antagonist.Product ApplicationIrbesartan has been used as an angiotensin II receptor type 1 (ATR1) blocker in carotid atheroma tissue. It may be used to test its effect on allergic asthma in rat and mice mast cells.

ALogP：4.1

PubChem SID：488179791

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488179791

IUPAC Name：2-butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one

INCHI：InChI=1S/C25H28N6O/c1-2-3-10-22-26-25(15-6-7-16-25)24(32)31(22)17-18-11-13-19(14-12-18)20-8-4-5-9-21(20)23-27-29-30-28-23/h4-5,8-9,11-14H,2-3,6-7,10,15-17H2,1H3,(H,27,28,29,30)

InChi Key：YOSHYTLCDANDAN-UHFFFAOYSA-N

Canonical SMILES：CCCCC1=NC2(CCCC2)C(=O)N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5

Isomeric SMILES：CCCCC1=NC2(CCCC2)C(=O)N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5

WGK Germany：3

关联CAS：138402-11-6

PubChem CID：3749

NSC Number：758696

MeSH Entry Terms：2-n-butyl-3-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-1,3-diazaspiro(4,4)non-1-en-4-one;Aprovel;Avapro;BMS 186295;BMS-186295;irbesartan;Karvea;SR 47436;SR-47436;SR47436

DrugBank Ligand：DB01029

CAS Registry No.：138402-11-6

ChEBI：CHEBI5959

Wikipedia：Irbesartan

ChEMBL Ligand：CHEMBL1513

BindingDB Ligand：50042235

PEP：irbesartan

Reactome Reaction：R-HSA-9615249

Reactome Drug：R-ALL-9615287

DrugCentral Ligand：1481

GPCRdb Ligand：irbesartan

溶解性：Soluble in DMSO (>25 mg/ml), ethanol (~0.5 mg/ml), methanol, DMF (~20 mg/ml), and water (<1 mg/ml at 25 °C).

熔点：188 °C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH412 Harmful to aquatic life with long lasting effectsH372 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn childH361 Suspected of damaging fertility or the unborn childH362 May cause harm to breast-fed children

预防措施声明：P261,P305+P351+P338,P273,P280,P302+P352,P321,P405,P501,P264,P260,P271,P270,P304+P340,P403+P233,P362+P364,P263,P203,P264+P265,P318,P337+P317,P332+P317,P319

Merck Index：5083

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