产品名称

英文名称：5'-Deoxy-5-fluorouridine

同义词

doxifluridine、5'-Deoxy-5-fluorouridine、5-fluoro-5'-deoxyuridine、Furtulon、3094-09-5、5'-Dfur、Flutron、Uridine, 5'-deoxy-5-fluoro-、Doxifluridina、Doxifluridinum、Fulturon、Ro 219738、Ro 21-9738、1-((2R,3R,4S,5R)-3,4-dihydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoro、5'-脱氧-5-氟尿苷、去氧氟尿苷、去氧氟尿苷/氟铁龙、卡培他滨杂质B、1-(5-脱氧-β-D-呋喃核糖基)-5-氟尿嘧啶、5'-脱氧-5-氟尿嘧啶核苷

产品性质

CAS编号：3094-09-5

分子式：C9H11FN2O5

分子量：246.19

MDL号：MFCD00866530

PubChem编号：18343

别名：5'-脱氧-5-氟尿苷|去氧氟尿苷|去氧氟尿苷/氟铁龙|卡培他滨杂质B|1-(5-脱氧-β-D-呋喃核糖基)-5-氟尿嘧啶|5'-脱氧-5-氟尿嘧啶核苷

英文别名：doxifluridine|5'-Deoxy-5-fluorouridine|5-fluoro-5'-deoxyuridine|Furtulon|3094-09-5|5'-Dfur|Flutron|Uridine, 5'-deoxy-5-fluoro-|Doxifluridina|Doxifluridinum|Fulturon|Ro 219738|Ro 21-9738|1-((2R,3R,4S,5R)-3,4-dihydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoro

规格或纯度：>98.0%(HPLC)

英文名称：5'-Deoxy-5-fluorouridine

生化机理：氟嘧啶。在体内显示抗肿瘤和抗血管生成作用。激活巨噬细胞中的NF-κB。口服具有活性活性代谢物5-氟尿嘧啶也可提供。

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Doxifluridine是胸苷磷酸化酶活化剂，对PC9-DPE2细胞的IC50为0.62 μM。Doxifluridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts transformed by H-ras or trk oncogenes. Possesses anticachectic activity which is independent of its antiproliferative activity.Doxifluridine (5'-DFUR, AMC 0101) is an oral prodrug that is converted to the cytotoxic agent 5-fluorouracil (5-FU).Doxifluridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts transformed by H-ras or trk oncogenes. Possesses anticachectic activity which is independent of its antiproliferative activity.

ALogP：-1.7

IUPAC Name：1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoropyrimidine-2,4-dione

INCHI：InChI=1S/C9H11FN2O5/c1-3-5(13)6(14)8(17-3)12-2-4(10)7(15)11-9(12)16/h2-3,5-6,8,13-14H,1H3,(H,11,15,16)/t3-,5-,6-,8-/m1/s1

InChi Key：ZWAOHEXOSAUJHY-ZIYNGMLESA-N

Canonical SMILES：CC1C(C(C(O1)N2C=C(C(=O)NC2=O)F)O)O

Isomeric SMILES：C[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=C(C(=O)NC2=O)F)O)O

RTECS：YU7526000

PubChem CID：18343

Reaxy-Rn：890191

比旋光度：20° (C=1,H2O)

熔点：189 °C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH351 Suspected of causing cancerH411 Toxic to aquatic life with long lasting effectsH317 May cause an allergic skin reactionH226 Flammable liquid and vaporH332 Harmful if inhaledH360 May damage fertility or the unborn childH340 May cause genetic defectsH350 May cause cancer

预防措施声明：P261,P305+P351+P338,P273,P280,P370+P378,P210,P302+P352,P321,P405,P501,P233,P240,P264,P403+P235,P303+P361+P353,P281,P271,P241,P304+P340,P403+P233,P272,P333+P313,P362+P364,P391,P242,P243,P203,P264+P265,P318,P317,P337+P317,P332+P317,P319

Merck Index：3437

产品包装