产品名称

英文名称：N,N,2-Trimethyl-5-nitrobenzenesulfonamide

同义词

433695-36-4、BRL-50481、BRL 50481、N,N,2-trimethyl-5-nitrobenzenesulfonamide、5-Nitro-2,N,N-trimethylbenzenesulfonamide、N,N,2-Trimethyl-5-nitro-benzenesulfonamide、Benzenesulfonamide, N,N,2-trimethyl-5-nitro-、BRL50481、CHEMBL484928、N,N,2-trimethyl-5-nitrobenzen

产品性质

CAS编号：433695-36-4

分子式：C9H12N2O4S

分子量：244.27

MDL号：MFCD03039912

PubChem编号：2921148

英文别名：433695-36-4|BRL-50481|BRL 50481|N,N,2-trimethyl-5-nitrobenzenesulfonamide|5-Nitro-2,N,N-trimethylbenzenesulfonamide|N,N,2-Trimethyl-5-nitro-benzenesulfonamide|Benzenesulfonamide, N,N,2-trimethyl-5-nitro-|BRL50481|CHEMBL484928|N,N,2-trimethyl-5-nitrobenzen

规格或纯度：≥98%

英文名称：N,N,2-Trimethyl-5-nitrobenzenesulfonamide

生化机理：BRL 50481 is a potent and selective PDE7 inhibitor (IC50 = 260 nM).Selective, competitive PDE7 inhibitor (IC 50 values are 0.15 and 12.1 μm for PDE7A and PDE7B respectively). Active in vivo and in vitro . Potentiates the anti-inflammatory effect of PDE4 inhibitor rolipram .

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：BRL-50481 is a selective inhibitor of phosphodiesterase 7 (PDE 7) that has acceptable selectivity for in vitro studies. Studies sμggest that BRL-50481 is used to inhibit the activity of hrPDE7A1 which is usually expressed in baculovirus-infected Spodoptera frμgiperda in a competitive manner. In osteoblasts, BRL-50481increases mineralization and bALP as a result of PDE7 silencing which upregulates several osteogenic genes. Further studies show that BRL-50481increases apoptosis in CLL cells via a mitochondrial-dependent process, and is associated with increased cAMP accumulation and down-regulation of the antiapoptotic protein survivin. BRL-50481 is a inhibitor of PDE7A.BRL-50481 is a selective inhibitor of phosphodiesterase 7 (PDE 7) that has acceptable selectivity for in vitro studies. Studies suggest that BRL-50481 is used to inhibit the activity of hrPDE7A1 which is usually expressed in baculovirus-infected Spodoptera frugiperda in a competitive manner. In osteoblasts, BRL-50481increases mineralization and bALP as a result of PDE7 silencing which upregulates several osteogenic genes. Further studies show that BRL-50481increases apoptosis in CLL cells via a mitochondrial-dependent process, and is associated with increased cAMP accumulation and down-regulation of the antiapoptotic protein survivin. BRL-50481 is a inhibitor of PDE7A.

IUPAC Name：N,N,2-trimethyl-5-nitrobenzenesulfonamide

INCHI：InChI=1S/C9H12N2O4S/c1-7-4-5-8(11(12)13)6-9(7)16(14,15)10(2)3/h4-6H,1-3H3

InChi Key：IFIUFCJFLGCQPH-UHFFFAOYSA-N

Canonical SMILES：CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N(C)C

Isomeric SMILES：CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N(C)C

WGK Germany：3

PubChem CID：2921148

CAS Registry No.：433695-36-4

Wikipedia：BRL-50481

ChEMBL Ligand：CHEMBL484928

敏感性：对热敏感

熔点：73 °C

个人防护装备：Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

产品包装