产品名称

英文名称：MPP+ iodide

同义词

MPP+ iodide、36913-39-0、1-Methyl-4-phenylpyridinium iodide、N-Methyl-4-phenylpyridinium iodide、1-Methyl-4-phenylpyridin-1-ium iodide、Cyperquat iodide、MPP+ (iodide)、1-methyl-4-phenylpyridin-1-ium;iodide、Pyridinium, 1-methyl-4-phenyl-, iodide、CHEMBL271379、N70、N-甲基-4-苯基吡啶鎓碘化物

产品性质

CAS编号：36913-39-0

分子式：C12H12IN

分子量：297.13

MDL号：MFCD00055096

PubChem编号：10924457

别名：N-甲基-4-苯基吡啶鎓碘化物

英文别名：MPP+ iodide|36913-39-0|1-Methyl-4-phenylpyridinium iodide|N-Methyl-4-phenylpyridinium iodide|1-Methyl-4-phenylpyridin-1-ium iodide|Cyperquat iodide|MPP+ (iodide)|1-methyl-4-phenylpyridin-1-ium;iodide|Pyridinium, 1-methyl-4-phenyl-, iodide|CHEMBL271379|N70

规格或纯度：≥98%

英文名称：MPP+ iodide

生化机理：MPP+ iodide is an active metabolite of dopaminergic neurotoxin MPTP.Dopaminergic selective neurotoxin. Active MPTP metabolite. Interferes with oxidative phosphorylation and induces mitochondrial dysfunction. Deplete cellular ATP. Shows Parkinson effects in vivo.

应用：An active metabolite of the dopaminergic neurotoxin MPTP.

运输条件：常规运输

备注：Unstable; make up solutions fresh and use immediately. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

产品介绍：产品介绍1-甲基-4-苯基吡啶（MPP+）可通过抑制纹状体突触体中的线粒体氧化还原功能而诱发神经毒性。它是一种潜在的神经毒素并可在动物模型中诱导帕金森症。它可通过在小脑颗粒神经元和神经母细胞瘤细胞中产生活性氧来介导细胞凋亡。MPP+可调控多巴胺的分布。它可通过激活神经元一氧化氮合酶（nNOS）而引起神经毒性，产生过量的一氧化氮。 产品应用 MPP+碘化物已用于 在斑马鱼胚胎中诱导氧化应激 抑制星形胶质细胞线粒体中谷氨酸的摄入 在小胶质细胞（BV2）中使用MTT（3（4,5-二甲基噻唑）-2-基-2,5-二苯基四唑溴化物）检测细胞活力Product Describtion1-Methyl-4-phenylpyridinium (MPP+) induces neurotoxicity by inhibiting mitochondrial redox functions in the striatal synaptosomes. It is a potential neurotoxin and induces Parkinson′s disease in animal models. It mediates apoptosis by the generation of reactive oxygen species in cerebellar granule neurons and neuroblastoma cells. MPP+ modulates the distribution of dopamine. It elicits neurotoxicity by activating neuronal nitric oxide synthase (nNOS), resulting in excess nitric oxide. Product Application MPP+ iodide has been used to induce oxidative stress in zebrafish embryos for the inhibition of glutamate uptake in mitochondria of astrocytes in testing cell viability using MTT (3 (4,5-dimethylthiazol)-2-yl-2,5-diphenyltetrazolium bromide) in microglia (BV2) cells

IUPAC Name：1-methyl-4-phenylpyridin-1-ium;iodide

INCHI：InChI=1S/C12H12N.HI/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-10H,1H3;1H/q+1;/p-1

InChi Key：RFDFRDXIIKROAI-UHFFFAOYSA-M

Canonical SMILES：C[N+]1=CC=C(C=C1)C2=CC=CC=C2.[I-]

Isomeric SMILES：C[N+]1=CC=C(C=C1)C2=CC=CC=C2.[I-]

WGK Germany：3

RTECS：UU6580000

PubChem CID：10924457

UN Number：2811

Packing Group：II

溶解性：H2O >10 mg/mL, soluble

敏感性：对光线和湿度敏感

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH301 Toxic if swallowedH311 Toxic in contact with skinH331 Toxic if inhaled

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P361+P364,P264+P265,P301+P316,P337+P317,P332+P317,P316,P319

Class：6.1

个人防护装备：Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

产品包装