产品名称

英文名称：A-317491

同义词

A-317491、475205-49-3、475205-49-3 (free acid)、1,2,4-Benzenetricarboxylic acid, 5-((((3-phenoxyphenyl)methyl)((1S)-1,2,3,4-tetrahydro-1-naphthalenyl)amino)carbonyl)-、H327N08IPV、5-{[(3-phenoxyphenyl)methyl][(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl}be

产品性质

CAS编号：475205-49-3

分子式：C33H27NO8

分子量：565.57

PubChem编号：9829395

英文别名：A-317491|475205-49-3|475205-49-3 (free acid)|1,2,4-Benzenetricarboxylic acid, 5-((((3-phenoxyphenyl)methyl)((1S)-1,2,3,4-tetrahydro-1-naphthalenyl)amino)carbonyl)-|H327N08IPV|5-{[(3-phenoxyphenyl)methyl][(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl}be

规格或纯度：≥98%

英文名称：A-317491

生化机理：A-317491 is a non-nucleotide P2X3 and P2X2/3 receptor antagonist, which inhibits calcium flux mediated by the receptors. It is known that P2X3 and P2X2/3 receptors stimulate the pronociceptive effects of ATP upon activation. Studies indicate that the P2X3 receptor is implicated in both neuropathic and inflammatory pain. P2X3 receptor is a promising target for therapeutic intervention in cancer patients for pain management.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：A-317491是非核苷酸类P2X3和P2X2/3受体拮抗剂，能抑制由其介导的钙流。A P2X3 and P2X2/3 receptor antagonistA-317491 is a non-nucleotide P2X3 and P2X2/3 receptor antagonist, which inhibits calcium flux mediated by the receptors.A P2X3 and P2X2/3 receptor antagonist

IUPAC Name：5-[(3-phenoxyphenyl)methyl-[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl]benzene-1,2,4-tricarboxylic acid

INCHI：InChI=1S/C33H27NO8/c35-30(25-17-27(32(38)39)28(33(40)41)18-26(25)31(36)37)34(29-15-7-10-21-9-4-5-14-24(21)29)19-20-8-6-13-23(16-20)42-22-11-2-1-3-12-22/h1-6,8-9,11-14,16-18,29H,7,10,15,19H2,(H,36,37)(H,38,39)(H,40,41)/t29-/m0/s1

InChi Key：VQGBOYBIENNKMI-LJAQVGFWSA-N

Canonical SMILES：C1CC(C2=CC=CC=C2C1)N(CC3=CC(=CC=C3)OC4=CC=CC=C4)C(=O)C5=CC(=C(C=C5C(=O)O)C(=O)O)C(=O)O

Isomeric SMILES：C1C[C@@H](C2=CC=CC=C2C1)N(CC3=CC(=CC=C3)OC4=CC=CC=C4)C(=O)C5=CC(=C(C=C5C(=O)O)C(=O)O)C(=O)O

关联CAS：475205-49-3

PubChem CID：9829395

MeSH Entry Terms：A-317491;A317491

ChEMBL Ligand：CHEMBL596234

CAS Registry No.：475205-49-3

RCSB PDB Ligand：71C

溶解性：DMSO

产品包装