产品名称

英文名称：N-Glycolylneuraminic Acid

同义词

Neu5Glc 、 NeuNGl、N-羟乙酰神经氨酸

产品性质

CAS编号：1113-83-3

分子式：C11H19NO10

分子量：325.27

Beilstein号：1716828

MDL号：MFCD00057551

PubChem编号：123802

别名：N-羟乙酰神经氨酸

英文别名：Neu5Glc | NeuNGl

规格或纯度：≥95% (HPLC)

英文名称：N-Glycolylneuraminic Acid

生化机理：N-glycolylneuraminic acid (Neu5Gc) is a hydroxylated form of the generally known sialic acid N-acetylneuraminic acid, Neu5Ac. The compound is biosynthesized by the activity of cytidine monophosphate-N-acetylneuraminate (CMP-Neu5Ac) hydroxylase. Humans do not express Neu5Gc because there is an absence of the hydroxylase acitivity required to convert CMP-Neu5Ac to CMP-Neu5Ac. This is due to a mutation in the gene that occurred after the Homo-Pan divergence. Research shows that the parasite Trypanosoma cruzi contains N-glycoloylneuraminic acid, but is unable to synthesize sialic acids from their precursors.

应用：在鼠肝内调控N-羟乙酰神经氨酸的生物合成。

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：N-羟乙酰神经氨酸（Neu5Gc）是最常见的唾液酸，它是由于N-乙酰神经氨酸（Neu5Ac）的5-N-乙酰结构单元中甲基的羟基化形成。它主要存在于海胆和海星中，也广泛分布于精子细胞和卵母细胞的糖蛋白和神经节苷脂中。Neu5Gc属于Sia家族。产品应用N-羟乙酰神经氨酸已被用于①作为微量滴定生物膜（microtiter biofilm ）方法中的糖用于改善生物膜形成；②作为标准品用于测定量蚕神经系统中的唾液酸，并用于发现不同发育阶段唾液酸的变化；③作为高效液相色谱（HPLC）分析中的标准品用于以1,2-二氨基-4,5-亚甲基二氧苯（DMB）为荧光化合物检测唾液酸（Sia）分子。N-Glycolylneuraminic acid (Neu5Gc) is the most common sialic acid formed as a result of the hydroxylation of the methyl group of the 5-N-acetyl moiety of N-acetylneuraminic acid (Neu5Ac). It is predominantly found in sea urchins and starfish and is broadly distributed in glycoproteins and gangliosides of sperm cells and oocyte. Neu5Gc belongs to the family of Sia.Product ApplicationN-Glycolylneuraminic acid has been used①as a sugar in microtiter biofilm methodologic approach for the enhancement of biofilm formation.②as a standard for the determination of sialic acids in the nervous system of silkworm and to find the variations of sialic acids among different developmental stages.③as a standard in the high-performance liquid chromatography (HPLC) analyses to detect the molecular species of sialic acid (Sia) species using 1,2-diamino-4,5-methylenedioxy-benzene (DMB) as a fluorogenic compound.

IUPAC Name：(2S,4S,5R,6R)-2,4-dihydroxy-5-[(2-hydroxyacetyl)amino]-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid

INCHI：InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/t4-,5+,7+,8+,9+,11-/m0/s1

InChi Key：FDJKUWYYUZCUJX-AJKRCSPLSA-N

Canonical SMILES：C1C(C(C(OC1(C(=O)O)O)C(C(CO)O)O)NC(=O)CO)O

Isomeric SMILES：C1[C@@H]([C@H]([C@@H](O[C@@]1(C(=O)O)O)[C@@H]([C@@H](CO)O)O)NC(=O)CO)O

WGK Germany：3

PubChem CID：123802

Reaxy-Rn：1716828

密度：1.75

敏感性：对热敏感

个人防护装备：Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

产品包装