产品名称

英文名称：Microcystin-LA

同义词

Microcystin-LA、Cyanoginosin LA、Microcystin LA、96180-79-9、MC-LA、Microcystin-leucine-alanine、Toxin BE 4 (Microcystis aeruginosa)、Cyanoginosin-LA、3E7C54U3SY、CHEMBL421377、(5R,8S,11R,12S,15S,18S,19S,22R)-18-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1

产品性质

CAS编号：96180-79-9

分子式：C46H67N7O12

分子量：910.06

PubChem编号：6437382

英文别名：Microcystin-LA|Cyanoginosin LA|Microcystin LA|96180-79-9|MC-LA|Microcystin-leucine-alanine|Toxin BE 4 (Microcystis aeruginosa)|Cyanoginosin-LA|3E7C54U3SY|CHEMBL421377|(5R,8S,11R,12S,15S,18S,19S,22R)-18-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1

规格或纯度：10ug/ml in methanol

英文名称：Microcystin-LA

生化机理：微囊藻毒素 LA 抑制蛋白磷酸酶类型 A 型和蛋白磷酸酶 3 类型的能力强于蛋白磷酸酶 1 类型（效价顺序 PP2A > PP3 > PP1）。诱导中性粒细胞活化趋化因子和胞外活性氧，可能的机制是其肝毒性作用。

应用：Microcystin LA 是一种天然毒素，Microcystin LA 通过抑制丝氨酸-苏氨酸蛋白磷酸酶 PP1 (IC50=0.3 nM) 和 PP2A (IC50=0.3 nM) 来发挥其细胞毒性作用。

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：产品介绍微囊藻毒素是一种单环小分子多肽，由 7 个氨基酸通过肽键连接而成。是一种具有肝毒性和促癌属性的青毒素。鱼腥藻属、 丝囊藻属、 微胞藻属 和 浮丝藻属等几个藻属产生微囊藻毒素。微囊藻毒素有四种同源物，即-LR、-LA、-YR 和-RR。产品用途Microcystin LA inhibit PP1 and PP2A quite potently and specifically relative to other known phosphatases, such as PP2B (calcineurin), PP2C, and the tyrosine phosphatasesProduct introductionMicrocystin is a small, monocyclic peptide, composed of seven amino acids connected via peptide bonds. It is a cyanotoxin with hepatotoxic and tumor promoting properties. Several algal genera like Anabaena, Aphanizomenon, Microcystis and Planktothrix produce microcystin.[2] Microcystin has four congeners namely, -LR, -LA, -YR and -RR.ApplicationMicrocystin LA inhibit PP1 and PP2A quite potently and specifically relative to other known phosphatases, such as PP2B (calcineurin), PP2C, and the tyrosine phosphatases

IUPAC Name：(5R,8S,11R,12S,15S,18S,19S,22R)-18-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dienyl]-1,5,12,15,19-pentamethyl-2-methylidene-8-(2-methylpropyl)-3,6,9,13,16,20,25-heptaoxo-1,4,7,10,14,17,21-heptazacyclopentacosane-11,22-dicarboxylic acid

INCHI：InChI=1S/C46H67N7O12/c1-24(2)21-35-44(60)52-38(46(63)64)28(6)40(56)47-29(7)41(57)49-33(18-17-25(3)22-26(4)36(65-11)23-32-15-13-12-14-16-32)27(5)39(55)50-34(45(61)62)19-20-37(54)53(10)31(9)43(59)48-30(8)42(58)51-35/h12-18,22,24,26-30,33-36,38H,9,19-21,23H2,1-8,10-11H3,(H,47,56)(H,48,59)(H,49,57)(H,50,55)(H,51,58)(H,52,60)(H,61,62)(H,63,64)/b18-17+,25-22+/t26-,27-,28-,29-,30+,33-,34+,35-,36-,38+/m0/s1

InChi Key：DIAQQISRBBDJIM-DRSCAGMXSA-N

Canonical SMILES：CC1C(NC(=O)C(NC(=O)C(C(NC(=O)C(NC(=O)C(NC(=O)C(=C)N(C(=O)CCC(NC1=O)C(=O)O)C)C)CC(C)C)C(=O)O)C)C)C=CC(=CC(C)C(CC2=CC=CC=C2)OC)C

Isomeric SMILES：C[C@H]1[C@@H](NC(=O)[C@@H](NC(=O)[C@H]([C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)C(=C)N(C(=O)CC[C@@H](NC1=O)C(=O)O)C)C)CC(C)C)C(=O)O)C)C)/C=C/C(=C/[C@H](C)[C@H](CC2=CC=CC=C2)OC)/C

WGK Germany：WGK 3

PubChem CID：6437382

溶解性：methanol 2 mg/mL

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH317 May cause an allergic skin reactionH300+H310+H330 Fatal if swallowed, in contact with skin or if inhaled

预防措施声明：P305+P351+P338,P280,P301+P310,P310,P302+P352,P304+P340,P330,P262

个人防护装备：Eyeshields, Faceshields, Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

RIDADR：UN 2811PIH 6.1 / PGI

产品包装