产品名称

英文名称：Dasatinib

同义词

BMS 354825、AR-270/43507994、Dasatinib (JAN/INN)、HMS3744C11、N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE、SB17284、Dasatinib - BMS-354825、DTXSID50235486、Pharmakon1600-01502275、AB、达沙替尼

产品性质

CAS编号：302962-49-8

分子式：C22H26ClN7O2S

分子量：488.01

EC号：801-607-0

PubChem编号：3062316

别名：达沙替尼

英文别名：BMS 354825|AR-270/43507994|Dasatinib (JAN/INN)|HMS3744C11|N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE|SB17284|Dasatinib - BMS-354825|DTXSID50235486|Pharmakon1600-01502275|AB

规格或纯度：≥99%

英文名称：Dasatinib

生化机理：Dasatinib is more effective than imatinib in inhibiting the proliferation of Ba/F3 cells expressing wild-type Bcr-Abl and Bcr-Abl mutants, with the exception of T315I. Dasatinib has a two-log (～325-fold) increased potency relative to imatinib. Dasatinib is a potent wild-type and mutant c-Abl inhibitor, except T315I. Dasatinib directly targets wild-type and mutant c-Abl kinase domains and inhibits autophosphorylation and substrate phosphorylation in a concentration-dependent manner. Dasatinib displays 325-fold greater potency compared with imatinib against cells expressing wild-type Bcr-Abl. Dasatinib treatment inhibits SRC signaling, decreases growth, and induces cell cycle arrest and apoptosis in a subset of thyroid cancer cells.Potent Src family tyrosine kinase (SFK)/Bcl-Abl kinase inhibitor. Inhibits growth of Bcr-Abl–dependent chronic myeloid leukemia xenografts in nude mice. Anti-tumor activity in vivo .

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Dasatinib是一种Src/Abl抑制剂，对生型Abl和Src激酶均有抑制作用，IC50分别为0.6 nM和0.8 nM。Directly targets wild-type and mutant c-Abl kinase domainsDasatinib is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM, respectively.Directly targets wild-type and mutant c-Abl kinase domains

ALogP：3.6

IUPAC Name：N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide

INCHI：InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)

InChi Key：ZBNZXTGUTAYRHI-UHFFFAOYSA-N

Canonical SMILES：CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CCO

Isomeric SMILES：CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CCO

关联CAS：302962-49-8,863127-77-9

PubChem CID：3062316

NSC Number：732517

MeSH Entry Terms：(18F)-N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide;354825, BMS;BMS 354825;BMS-354825;BMS354825;dasatinib;N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methyl

CAS Registry No.：302962-49-8

Wikipedia：Dasatinib

DrugBank Ligand：DB01254

DiscoveRx TREEspot：Dasatinib|

ChEMBL Ligand：CHEMBL1421

RCSB PDB Ligand：1N1

PEP：dasatinib

Reactome Reaction：R-HSA-9669855, R-HSA-9669854, R-HSA-9669900, R-HSA-9674430, R-HSA-9674095

Reactome Drug：R-ALL-9669723

DrugCentral Ligand：785

溶解性：Soluble in DMSO (200 mg/mL), ethanol (very poorly ), and water (very poorly ).

敏感性：对空气和热敏感

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH301 Toxic if swallowedH351 Suspected of causing cancerH318 Causes serious eye damageH410 Very toxic to aquatic life with long lasting effectsH372 Causes damage to organs through prolonged or repeated exposureH361 Suspected of damaging fertility or the unborn child

预防措施声明：P273,P280,P302+P352,P321,P405,P501,P264,P260,P270,P362+P364,P391,P330,P203,P264+P265,P301+P316,P305+P354+P338,P318,P317,P332+P317,P319

产品包装