产品名称

英文名称：Tolbutamide

同义词

tolbutamide、64-77-7、Orinase、Arkozal、Willbutamide、Butamide、Diabetamid、Ipoglicone、Glyconon、Rastinon、Tolbutamid、Aglicid、Artosin、Diaben、Tolumid、1-Butyl-3-tosylurea、Diasulfon、Artozin、Butamid、Diabetol、Diabuton、Dirastan、Dolipol、Mobenol、Oterben、Pramidex、Tolbusal、甲糖宁、N-(丁基氨基甲酰基)-4-甲基苯磺酰胺、1-丁基-3-(4-甲基苯磺酰基)脲

产品性质

CAS编号：64-77-7

分子式：C12H18N2O3S

分子量：270.35

MDL号：MFCD00027169

PubChem编号：5505

别名：甲糖宁|N-(丁基氨基甲酰基)-4-甲基苯磺酰胺|1-丁基-3-(4-甲基苯磺酰基)脲

英文别名：tolbutamide|64-77-7|Orinase|Arkozal|Willbutamide|Butamide|Diabetamid|Ipoglicone|Glyconon|Rastinon|Tolbutamid|Aglicid|Artosin|Diaben|Tolumid|1-Butyl-3-tosylurea|Diasulfon|Artozin|Butamid|Diabetol|Diabuton|Dirastan|Dolipol|Mobenol|Oterben|Pramidex|Tolbusal|

规格或纯度：≥99%

英文名称：Tolbutamide

生化机理：ATP敏感（KIR6.x）内向整流器K +通道的阻止器。

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：1g卖完停产，不再备货。如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Tolbutamide is a sulfonylurea agonist for secretion of insulin by beta-cells. In rat pancreatic beta-cells cultured in the presence of Tolbutamide displayed increased numbers of beta-cells in a dose responsive manner with beta-cell numbers doubling at 100 μg/ml of Tolbutamide. The compound displayed inhibitory action towards beta-cells at concentrations greater than 100 μg/ml. In addition in the presence of low glucose concentrations Tolbutamide’s cytotrophic action was inhibited. On isolated dog pancreas islets Tolbutamide at 180 μM stimulated the release of somatostatin, insulin and glucagon in the absence of glucose. in all situations the loss of Ca2+ eliminated all effects of Tolbutamide. The compound has been observed to mechanistically enhance the secretion of insulin by highly selective amplification of insulin secretory burst mass.Tolbutamide is a sulfonylurea agonist for secretion of insulin by beta-cells. In rat pancreatic beta-cells cultured in the presence of Tolbutamide displayed increased numbers of beta-cells in a dose responsive manner with beta-cell numbers doubling at 100 μg/ml of Tolbutamide. The compound displayed inhibitory action towards beta-cells at concentrations greater than 100 μg/ml. In addition in the presence of low glucose concentrations Tolbutamide’s cytotrophic action was inhibited. On isolated dog pancreas islets Tolbutamide at 180 μM stimulated the release of somatostatin, insulin and Glukagon in the absence of glucose. in all situations the loss of Ca2+ eliminated all effects of Tolbutamide. The compound has been observed to mechanistically enhance the secretion of insulin by highly selective amplification of insulin secretory burst mass.

ALogP：2.3

IUPAC Name：1-butyl-3-(4-methylphenyl)sulfonylurea

INCHI：InChI=1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)

InChi Key：JLRGJRBPOGGCBT-UHFFFAOYSA-N

Canonical SMILES：CCCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)C

Isomeric SMILES：CCCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)C

PubChem CID：5505

DrugBank Ligand：DB01124

CAS Registry No.：64-77-7

ChEMBL Ligand：CHEMBL782

Wikipedia：Tolbutamide

DrugCentral Ligand：2696

溶解性：Soluble in DMSO or 100% ethanol; insoluble in water.

熔点：127 °C

象形图：

信号词：Danger

危险声明：H302 Harmful if swallowedH317 May cause an allergic skin reactionH370 Causes damage to organsH361 Suspected of damaging fertility or the unborn child

预防措施声明：P261,P280,P302+P352,P321,P405,P501,P264,P260,P270,P272,P333+P313,P362+P364,P330,P203,P301+P317,P318,P308+P316

Merck Index：9507

产品包装